Major Kaposi's sarcoma discovery announced

Apr 06, 2006

Government scientists say they've found a human cell surface molecule involved with the Kaposi's sarcoma herpes virus.

The researchers at the National Institute of Allergy and Infectious Disease say the molecule xCT is a major gateway the herpes virus uses to enter human cells and might also play a role in the development of Kaposi's sarcoma and other syndromes associated with the virus.

The natural function of xCT is to transport molecules necessary for protecting against stress into cells. When cells are stressed, they express more xCT. Such stress can be caused by KSHV itself and that, scientists say, suggests the virus may cause itself to be more effective.

"Understanding the mechanisms of cell entry of Kaposi's sarcoma herpes virus is a landmark achievement in and of itself," said NIAID Director Dr. Anthony Fauci. "But the connection between the virus and expression of its own receptor on a cell is even more provocative because it might change the way we think about (Kaposi's sarcoma herpes virus-associated) diseases and their treatment."

The research appears in the journal Science.

Copyright 2006 by United Press International

Explore further: Fear of losing money, not spending habits, affects investor risk tolerance, study finds

add to favorites email to friend print save as pdf

Related Stories

Longevity of AIDS patients presents new risks: US

Jun 02, 2011

Thirty years after the AIDS epidemic first surfaced, more people than ever before in the United States -- more than 1.1 million -- are living with HIV, the Centers for Disease Control said Thursday.

Researchers identify new drug target for Kaposi's sarcoma

Jul 30, 2009

UCSF researchers have identified a new potential drug target for the herpes virus that causes Kaposi's sarcoma, re-opening the possibility of using the class of drugs called protease inhibitors against the full herpes family ...

Detecting disease with a smartphone accessory

Jun 04, 2013

As antiretroviral drugs that treat HIV have become more commonplace, the incidence of Kaposi's sarcoma, a type of cancer linked to AIDS, has decreased in the United States. The disease, however, remains prevalent ...

Premature aging seen as issue for AIDS survivors

Jun 11, 2011

(AP) -- Having survived the first and worst years of the AIDS epidemic, when he was losing three friends to the disease in a day and undergoing every primitive, toxic treatment that then existed, Peter Greene ...

Recommended for you

F1000Research brings static research figures to life

13 hours ago

F1000Research today published new research from Bjorn Brembs, professor of neurogenetics at the Institute of Zoology, Universitaet Regensburg, in Germany, with a proof-of-concept figure allowing readers and reviewers to run ...

How science can beat the flawed metric that rules it

14 hours ago

In order to improve something, we need to be able to measure its quality. This is true in public policy, in commercial industries, and also in science. Like other fields, science has a growing need for quantitative ...

User comments : 0