Nanogen Issued Patent for Ligation-Based Strand Displacement Amplification Technologies for DNA Analysis

Mar 16, 2005

Nanogen, Inc., developer of advanced diagnostic products, announced today that it was issued U.S. Patent No. 6,864,071, "Multiplex amplification and separation of nucleic acid sequences using ligation-dependent strand displacement amplification and bioelectronic chip technology," by the U.S. Patent and Trademark Office. The '071 patent relates to amplifying and analyzing multiple samples of nucleic acid using ligation-based strand displacement amplification (SDA) technologies. The intellectual property pertains to research Nanogen conducted in collaboration with Becton Dickinson and increases Nanogen's portfolio of technologies for multiplex amplification on a chip.

The combination of SDA and Nanogen chip technologies makes it possible to conduct multiplex amplification, detection and analysis of multiple samples within a single electronic microarray. Unlike techniques that rely on thermal cycling, SDA is an isothermal amplification process that utilizes a series of primers, DNA polymerase and a restriction enzyme to exponentially amplify the target nucleic acid sequence. The devices and methods of Nanogen's invention may be useful in a variety of applications, including disease diagnostics, genetic analyses, drug discovery, pharmacogenomics, and agricultural and environmental applications.

This new patent expands Nanogen's intellectual property portfolio to include 113 patents issued in the U.S.

Explore further: Nanoparticles release drugs to reduce tooth decay

Related Stories

Researchers discover a way to detect new viruses

Jun 17, 2013

(Phys.org) —In research published in Biochemical and Biophysical Research Communications, Saint Louis University researchers describe a technology that can detect new, previously unknown viruses. The te ...

New technology modifies music hall acoustics

May 31, 2013

A new technology that relies on a system of inflatable sound absorbers may help make any performance hall instantly convertible into a venue for music ranging from classical to hard rock. The technology will be described ...

Recommended for you

Nanoparticles release drugs to reduce tooth decay

12 hours ago

Therapeutic agents intended to reduce dental plaque and prevent tooth decay are often removed by saliva and the act of swallowing before they can take effect. But a team of researchers has developed a way ...

Combining magnetism and light to fight cancer

17 hours ago

By combining, in a liposome, magnetic nanoparticles and photosensitizers that are simultaneously and remotely activated by external physical stimuli (a magnetic field and light), scientists at the Laboratoire ...

Natural nanocrystals shown to strengthen concrete

Mar 31, 2015

Cellulose nanocrystals derived from industrial byproducts have been shown to increase the strength of concrete, representing a potential renewable additive to improve the ubiquitous construction material.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.