Anti-aging hormone actions revealed

Nov 03, 2005

Scientists say the recently discovered anti-aging hormone "Klotho" acts by increasing a cell's ability to detoxify harmful reactive oxygen species.

The klotho gene -- named after the Greek goddess who spins life's thread -- is associated with preventing aging in mammals. The klotho gene product, the Klotho protein, is secreted in the blood and functions as an anti-aging hormone.

A defect in the klotho gene in mice leads to a syndrome closely resembling human aging, while over-expression of the gene extends lifespan in mice.

Now Makoto Kuro-o, assistant professor of pathology at the University of Texas Southwestern Medical Center, has discovered one way in which Klotho extends lifespan. Using cultured cells and transgenic mice, the researcher showed Klotho increases resistance to oxidative stress.

"Increased longevity is always associated with increased resistance to oxidative stress," said Kuro-o. "Oxidative stress causes the accumulation of oxidative damage to important biological macromolecules, such as DNA, lipids, and proteins that would result in functional deterioration of the cell, which eventually causes aging."

The research appears as the "Paper of the Week" in the Nov. 11 issue of the Journal of Biological Chemistry.

Copyright 2005 by United Press International

Explore further: Mapping the world's linguistic diversity—scientists discover links between your genes and the language you speak

Related Stories

Recommended for you

Lady, you're on the money

21 hours ago

So far, women whose portraits appear on U.S. money have been a party of three. Excluding commemorative currency, only Sacagawea, Susan B. Anthony and Helen Keller appear on coins in general circulation, according ...

Old World monkey had tiny, complex brain

22 hours ago

The brain hidden inside the oldest known Old World monkey skull has been visualized for the first time. The creature's tiny but remarkably wrinkled brain supports the idea that brain complexity can evolve ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.