Using a promiscuous inhibitor to uncover cancer drug targets

Scientists at Harvard Medical School and the Dana-Farber Cancer Institute have developed a method that exploits the multitargeted nature of a chemical inhibitor to pinpoint vulnerabilities within cancer cells.

How a certain bacterium communicates and makes us sick

Researchers at Binghamton University, State University of New York have uncovered the unique way in which a type of Gram-negative bacterium delivers the toxins that make us sick. Understanding this mechanism may help design ...

How do protein tangles get so long in Alzheimer's?

Early in the course of Alzheimer's disease—long before future patients begin to notice symptoms—neurofibrillary tangles composed of tau protein aggregates begin to form in their brain cells. How toxic these aggregates ...

Anticancer mechanism revealed in yeast experiments

Much like shoelaces or dangly necklaces, DNA strands can tangle up in unruly knots. Specialized enzymes keep DNA organized when cells divide, so the cells split smoothly and don't get stuck. But in tumor cells, this failsafe ...

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