Genomes, as physical systems, comprise the complete set of nucleic acid molecules (typically DNA, or RNA in some viruses) that encode the hereditary information of an organism, including all chromosomes and extrachromosomal genetic elements. They are organized into linear or circular polymers of nucleotides, with specific higher-order structures such as chromatin in eukaryotes or nucleoid organization in prokaryotes. At the physical level, genomes exhibit defined sequence composition, length, and structural features (e.g., replication origins, regulatory regions, repetitive elements) that collectively determine their stability, replication dynamics, mutational patterns, and interactions with cellular molecular machinery.
For researchers on the hunt for the genetic roots of disease, the cost of deep whole-genome sequencing makes it challenging to conduct large genetic studies involving thousands of participants, which are needed to reveal ...
Molecular & Computational biology
Jul 12, 2026
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75
Nature is beautiful, powerful and essential. But nature is not always gentle. The same biological world that gives rise to forests, coral reefs and human life also produces infections, cancer, genetic disease, crop blights ...
Cell & Microbiology
Jul 12, 2026
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14
Phylo-Plex, a new computational method, has been developed by Wellcome Sanger Institute scientists and their collaborators to allow cost-effective and scalable DNA sequencing of pathogens in laboratories with limited resources. ...
Molecular & Computational biology
Jul 9, 2026
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19
Much of the genome is made up of repetitive DNA sequences that trace back to ancient mobile elements, many of which have lost their ability to copy themselves into new locations but can still cause problems if they become ...
Cell & Microbiology
Jul 8, 2026
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6
In a study published in Science Translational Medicine, a team of researchers led by Dr. Wang Yu from the Shenzhen Institutes of Advanced Technology of the Chinese Academy of Sciences developed PRINCE and Little Prince, dual ...
Biotechnology
Jul 3, 2026
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77
Researchers have spent decades—and billions of dollars—sequencing animal and crop genomes, but fungi have historically been the forgotten middle child of genomics, only noticed when they're ruining bread or colonizing toes.
Biotechnology
Jul 3, 2026
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124
In the study of bacteria, a longstanding dogma has held that two molecular machines—RNA polymerase, which leads the way in transcribing DNA into RNA, and ribosomes, which bring up the rear translating RNA into proteins—worked ...
Cell & Microbiology
Jul 2, 2026
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10
All living organisms are known to inherit genes, DNA sequences that contain instructions for producing specific proteins and performing biological functions, from their parents. In some cases, however, genes can also shift ...
Decades-old hospital samples have helped University of East Anglia (UEA) researchers uncover how a deadly antibiotic-resistant "superbug" quietly tightened its grip across the globe. It lurked in hospital corridors for decades, ...
Evolution
Jul 1, 2026
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203
A new evolutionary theory suggests that some asexual parasites may temporarily be able to infect a wider range of hosts as harmful genetic mutations build up. In a paper published in Trends in Parasitology, Cock van Oosterhout, ...
Cell & Microbiology
Jul 1, 2026
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