Two biologics studied for multiple myeloma

Mar 14, 2007

U.S. medical scientists report investigating two novel biologics for their potential benefit to multiple myeloma patients.

The separate clinical trials are being conducted at the NewYork-Presbyterian Hospital/Weill Cornell Medical Center.

A Phase 2 trial with VEGF Trap will assess the drug's ability to slow tumor growth in patients with multiple myeloma. VEGF Trap is a recombinant human fusion protein that binds VEGF, a key molecule in tumor blood-vessel growth (angiogenesis).

The other investigation is a Phase 1 trial of hLL1, a humanized monoclonal antibody that has shown significant growth inhibition of multiple myeloma and B-lymphoma cells in preclinical studies.

"These two exciting antibody trials may give new hope to myeloma patients with relapsed and refractory disease," said Dr. Ruben Niesvizky, principal investigator of both studies.

Multiple myeloma is a blood cancer that causes white blood cells to become malignant and attack the body's bones, resulting in painful fractures, kidney failure and death. The disease affects an estimated 40,000 Americans annually.

Copyright 2007 by United Press International

Explore further: Everything you wanted to know about mitochondrial mutations but were afraid to ask

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Among gut microbes, strains, not just species, matter

5 hours ago

A large community of microorganisms calls the human digestive tract home. This dynamic conglomerate of microscopic life forms - the gut microbiome - is vital to how people metabolize various nutrients in ...

Scientists develop compound to fight MRSA

5 hours ago

Microbiologists and chemists at the University of South Florida have developed and patented a synthetic compound that has shown antibiotic action against methicillin resistant Staphylococcus aureus, also k ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.