Gene variations contribute to aggression and anger in women

Mar 09, 2007

Ever wonder why some women seem to be more ill-tempered than others? University of Pittsburgh researchers have found that behaviors such as anger, hostility and aggression may be genetic, rooted in variations in a serotonin receptor gene.

Indrani Halder, Ph.D., of the Cardiovascular Behavioral Medicine Program at the University of Pittsburgh, will present the findings today at the American Psychosomatic Society's Annual Meeting, held in Budapest, Hungary.

Previous studies have associated the hormone serotonin with anger and aggression in both humans and animals and have shown that increased serotonin activity is related to a decrease in angry and aggressive behaviors. In the study being presented today, researchers sought to determine if this relationship was genetically determined. The study is the first to look at the relationship between variations in the serotonin receptor 2C gene and anger and hostility.

Completed at the University of Pittsburgh's Behavioral Physiology Laboratory, the study looked at 550 unrelated women of European descent. In order to find normal variations in genes and behavior, the women were not prescreened for behavioral type. Researchers found that those who had one or both of two alterations in the promoter region of the serotonin receptor 2C gene were more likely to score lower on two common tests for anger, hostility and aggression.

These findings may aid in establishing a potential marker for certain conditions associated with aggression and anger.

"Aggression and hostility are predictors of hypertension, glucose metabolism and heart diseases," said Dr. Halder. "The genetic marker we found for hostility also may be useful for predicting a person's predisposition to such diseases."

Source: University of Pittsburgh Schools of the Health Sciences

Explore further: Novel gene variants found in a difficult childhood immune disorder

add to favorites email to friend print save as pdf

Related Stories

Korean tech start-ups offer life beyond Samsung

4 hours ago

As an engineering major at Seoul's Yonsei University, Yoon Ja-Young was perfectly poised to follow the secure, lucrative and socially prized career path long-favoured by South Korea's elite graduates.

Fresh nuclear leak detected at Fukushima plant

16 hours ago

Sensors at the Fukushima nuclear plant have detected a fresh leak of highly radioactive water to the sea, the plant's operator announced Sunday, highlighting difficulties in decommissioning the crippled plant.

Spacewalking astronauts route cable in 1st of 3 jobs

16 hours ago

(AP)—Spacewalking astronauts routed more than 300 feet (90 meters) of cable outside the International Space Station on Saturday, tricky and tiring advance work for the arrival of new American-made crew ...

Recommended for you

Exploring the genetic origins of autism

Feb 25, 2015

The geneticist SĂ©bastien Jacquemont is the new holder of the Canada Research Chair in Genetics of Neurodevelopmental Disorders and Associated Dysregulation in Energy Balance at the University of Montreal. He moved to the ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.