Fatigue in women is reduced in stress-related cortisol study

Nov 13, 2006

A study of healthy women has harvested results involving fatigue and vigor that eventually may help researchers fine tune efforts to treat a multitude of illnesses and syndromes linked to low levels of the stress hormone cortisol.

That low cortisol levels are found in such maladies as chronic fatigue syndrome, post-traumatic stress disorder, fibromyalgia and atypical depression is not new. However, the study, published in the November issue of Psychophysiology, combined with other findings emerging from a comprehensive project, appear to support the idea that sex hormones tend to separate men from women in their reactions to stress, said Mattie Tops, a postdoctoral research associate in the NeuroInformatics Center at the University of Oregon.

The study is the first to demonstrate improvements in fatigue and vigor in healthy female subjects, a finding that "is particularly relevant because of the high prevalence of hypocortisolemic fatigue syndromes in women and the association in healthy women between low morning cortisol levels and complaints of fatigue and muscular pain," Tops and his colleagues wrote in their conclusion.

In the study, 27 healthy women between the ages of 30-55, who met certain medical criteria and agreed to certain restrictions in diet, were given either placebos or capsules containing 35 milligrams of cortisol during morning sessions. After reading or resting for 70 minutes, blood was taken for sampling. Then participants performed an hour of computer-based tasks involving working memory, free recall, recognition memory and selective attention.

During this time, fatigue increased and vigor decreased, but those women who had received the cortisol reported a lesser increase in fatigue and higher vigor than did the women receiving placebos. The impact on fatigue levels was the most significant. The morning testing coincided with the time period in which naturally occurring cortisol levels are at their highest.

"In this study, we used healthy subjects who you wouldn't expect to have low cortisol levels," Tops said. "But fatigue is highly prevalent in women. It was kind of surprising that we found this at all. It may be a temporary effect of energy mobilization in conjunction with the cortisol administration, but the findings that cortisol ingestion provided positive results draw attention to those syndromes that are characterized by low cortisol levels."

The study was done in the Netherlands and is just one part of a larger project being done by Tops, a native of the Netherlands, and researchers at the University of Groningen and University Medical Center Groningen. A larger, not-yet-published study by the collaborators has found an association between low levels of cortisol and reports of high fatigue in women.

Tops is exploring a variety of interconnections involved in low cortisol levels, but not necessarily for the development of difficult-to-deliver cortisol-based treatments because of a long list of negative side effects that occur when levels are not accurately regulated. Cortisol supplementation has helped in some cases of post-traumatic stress disorder and chronic fatigue syndrome.

One issue that Tops and colleagues are seeking to address in some of their studies is the possibility that a sex difference in stress response is involved in hypocortisolemic syndromes. Some findings, Tops said, fit in nicely with a study led by UCLA's Shelley E. Taylor and published in Psychological Review in 2000. Taylor's study proposed that women have evolved to respond differently than males to stress, adopting a "tend-and-befriend" reaction. Most studies call major responses to stress as a fight-or-flight mechanism in which hormones activate the nervous system for fighting for territory or fleeing for safety.

Taylor and colleagues argued that almost all such studies have involved male animals and men, and that women instead have selectively evolved a mechanism to assure the survival of self and children. To do so, women went about befriending others and forming social groups to reduce risk. Hormonal responses, they argued, thus have developed differently for men and women.

A key to treatment of low cortisol levels, Tops said, likely will involve the development of pharmaceuticals that target specific components involved in the interaction of various hormones in various medical conditions.

Source: University of Oregon

Explore further: When it hurts to think we were made for each other

add to favorites email to friend print save as pdf

Related Stories

4.5 million grant for study of yoga and cancer

Apr 12, 2010

In an ongoing effort to scientifically validate the age-old belief that mind-body interventions have a beneficial impact on the health of patients, The University of Texas M. D. Anderson Cancer Center has been awarded more ...

Respiratory rhythms can help predict insomnia

Oct 20, 2008

The breathing and heart rates and cortisol levels of women with metastatic breast cancer can be used to predict if they'll suffer from chronic insomnia and sleep disruptions, a common complaint from patients who want to maintain ...

For women, marital distress means less relief from stress

Jan 01, 2008

That's the suggestion from a new UCLA study that tracked levels of cortisol, a key stress hormone, among 30 Los Angeles married couples involved in one of our age's trickiest juggling acts — raising kids when both parents ...

Recommended for you

When it hurts to think we were made for each other

3 hours ago

Aristotle said, "Love is composed of a single soul inhabiting two bodies." Poetic as it is, thinking that you and your partner were made in heaven for each other can hurt your relationship, says a new study.

User comments : 0