Researchers find genetic marker for repeat lung cancer

Aug 19, 2010

Current lung cancer survival statistics present a grim prognosis, but new findings could greatly impact survival rates. Researchers led by Lan Guo, Ph.D. at the West Virginia University Mary Babb Randolph Cancer Center have identified a gene pattern associated with lung cancer patients who are at high risk for recurrence of the disease.

Lung cancer recurs in nearly half of early stage patients who initially receive surgery, usually proving fatal. If doctors could predict whose cancer will come back, they could develop a more individualized, effective treatment strategy for each patient.

The team of WVU researchers has determined that a specific sequence of 12 genes can be used as a prognostic tool. Their work “Hybrid Models Identified a 12-Gene Signature for Lung Cancer Prognosis and Chemoresponse Prediction” haa been published in the August 17 edition of , an international, peer-reviewed, online publication of the U.S. Public Library of Science.

“Using a computational model to analyze 442 patient samples, we found that the 12-gene signature was more accurate in predicting lung cancer recurrence than other gene signatures documented in articles previously published in the ‘’ and ‘Nature Medicine’,” Dr. Guo said. “We also found that the could predict response to chemotherapy in cancer cell lines, indicating its potential use to predict patient response to chemotherapy commonly used to treat lung cancer.”

WVU has filed for a patent on the 12-gene signature. Guo’s group has already been successful in identifying specific genes found in lung cancer tumors.

Guo is a faculty member of the WVU Department of Community Medicine and part of the Center of Biomedical Research Excellence (COBRE) for Signal Transduction and Cancer, led by Laura Gibson, Ph.D., the Cancer Center’s deputy director.

Explore further: New cancer vaccine approach directly targets dendritic cells

More information: To view the research online see

Provided by West Virginia University

not rated yet
add to favorites email to friend print save as pdf

Related Stories

Gene signature may improve colon cancer treatment

Feb 26, 2010

A gene signature, first identified in mouse colon cancer cells, may help identify patients at risk of colon cancer recurrence, according to a recent study by Vanderbilt-Ingram Cancer Center researchers.

Researchers develop new method to test for lung cancer

Apr 01, 2008

Researchers from Boston University School of Medicine have developed a new “clinicogenomic model” to accurately test for lung cancer. The model combines a specific gene expression for lung cancer as well as clinical ...

Recommended for you

Unraveling the 'black ribbon' around lung cancer

2 hours ago

It's not uncommon these days to find a colored ribbon representing a disease. A pink ribbon is well known to signify breast cancer. But what color ribbon does one think of with lung cancer?

Survival hope for melanoma patients thanks to new vaccine

8 hours ago

(Medical Xpress)—University of Adelaide researchers have discovered that a new trial vaccine offers the most promising treatment to date for melanoma that has spread, with increased patient survival rates and improved ability ...

User comments : 0

More news stories

Turning off depression in the brain

Scientists have traced vulnerability to depression-like behaviors in mice to out-of-balance electrical activity inside neurons of the brain's reward circuit and experimentally reversed it – but there's ...

Proper stem cell function requires hydrogen sulfide

Stem cells in bone marrow need to produce hydrogen sulfide in order to properly multiply and form bone tissue, according to a new study from the Center for Craniofacial Molecular Biology at the Herman Ostrow School of Dentistry ...

There's something ancient in the icebox

Glaciers are commonly thought to work like a belt sander. As they move over the land they scrape off everything—vegetation, soil, and even the top layer of bedrock. So scientists were greatly surprised ...

Clean air: Fewer sources for self-cleaning

Up to now, HONO, also known as nitrous acid, was considered one of the most important sources of hydroxyl radicals (OH), which are regarded as the detergent of the atmosphere, allowing the air to clean itself. ...