Women with polycystic ovary syndrome have higher BPA blood levels

Jun 21, 2010

Women with the polycystic ovary syndrome (PCOS), the most common hormone imbalance in women of reproductive age, may be more vulnerable to exposure to the chemical bisphenol A (BPA), found in many plastic household items, according to a new study. The results will be presented Sunday at The Endocrine Society's 92nd Annual Meeting in San Diego.

The study found that BPA, a known hormone disrupter, is elevated and associated with higher levels of in the blood of women with PCOS compared with healthy women. These findings held true for both lean and obese women with PCOS, said Evanthia Diamanti-Kandarakis, MD, PhD, study co-author and professor at the University of Athens Medical School in Greece.

"Women with the polycystic ovary syndrome should be alert regarding this environmental contaminant's potential adverse effects on reproductive aspects of their health problem," she said.

Excessive secretion of androgens—masculinization-promoting hormones—occurs in PCOS. The syndrome raises the risk of infertility, obesity, Type 2 diabetes and heart disease.

Past studies show that BPA is elevated in women who have had recurrent miscarriages. This chemical can leach into the bloodstream from food and beverage containers that are made of polycarbonate hard plastic or lined with epoxy resins, or from some dental sealants and composites.

In the new study, the researchers divided 71 women with PCOS and 100 healthy female control subjects into subgroups matched by age and (obese or lean). Blood levels of BPA, compared with those of controls, were nearly 60 percent higher in lean women with PCOS and more than 30 percent higher in obese women with the syndrome.

Additionally, as the BPA blood level increased, so did the concentrations of the male sex and androstenedione, a steroid hormone that converts to testosterone, Diamanti-Kandarakis reported.

Although BPA is a weak estrogen, excessive secretion of androgens, as seen in PCOS, interfere with BPA detoxification by the liver, leading to accumulation of blood levels of BPA, Diamanti-Kandarakis explained.

"BPA also affects androgen metabolism, creating a vicious circle between androgens and BPA," she said.

Diamanti-Kandarakis said women with PCOS may want to limit their exposure to BPA.

"However," she said, "no one has proved that by reducing BPA levels in PCOS, it will have beneficial effects."

Explore further: UK dyslexia charities should give balanced view on expensive lenses to improve reading

add to favorites email to friend print save as pdf

Related Stories

Women with hormonal disorder at risk of heart disease

Apr 12, 2010

(PhysOrg.com) -- University of Adelaide researchers have found evidence of a link between a common hormonal disorder in women and heart disease - and they're seeking more women to take part in a new study ...

Consider Metabolic Complications With PCOS

Feb 19, 2010

(PhysOrg.com) -- Polycystic ovarian syndrome (PCOS) is one of the most common endocrine disorders in women of child-bearing age and is often discovered when women seek medical attention for reproductive difficulties or infertility. ...

Recommended for you

New analysis questions use of acute hemodialysis treatment

6 hours ago

A common approach to treating kidney failure by removing waste products from the blood did not improve survival chances for people who suddenly developed the condition, in an analysis led by experts at the University of Pittsburgh ...

User comments : 0