Intrahepatic clear cell cholangiocarcinoma

Jun 02, 2010

Intrahepatic cholangiocarcinoma (ICC) is a cancer of the bile duct in the liver. The clear cell subtype of ICC is a rare cancer; until now, only 8 cases have been reported. The number of reports is so small that a detail description of clear cell ICC is valuable.

A case report will be published on May 28, 2010 in the addresses this question. The diagnostic pathology team led by Associate Professor Dr. Hayashi at the Department of Pathology, Nagasaki University Hospital in Japan collaborated with Professor Nagayasu, Department of the 1st Surgery and Professor Uetani, Department of Radiology, to investigate how the specific "clear cell" change occurs, a patient's underlying disease and choice of chemotherapy, and the prognosis for future patients of this rare cancer.

The patient was a 56-year-old Japanese man with a 3-year histry of virus (HBV) infection. The follow-up echo revealed a tumor of the liver. CT and MRI suggested hepatocellular carcinoma (HCC); a cancer of . The patient had surgery and the tumor was diagnosed as the rare "clear cell ICC", not a conventional HCC.

Unlike reported cases, this patient had HBV infection as the underlying disease. The cell of conventional ICC is usually small and its nucleus occupies a large part of the cell. Clear cell ICC consists of larger cells with copious possibly caused by mucin, lipid, glycogen or by another unknown reason. Therefore the cells look clear. The originating from bile ducts often produce much mucin, however the clear cells in this case did not contain mucin, and had a little glycogen.

The literature review disclosed that the risk of metastasis or recurrence is low after the removal of the cancer. There is not enough evidence for the use of any particular treatment including chemotherapy. Therefore, careful follow-up and the acquisition of more case records are important to obtain more evidence on this cancer.

Explore further: FDG-PET/CT shows promise for breast cancer patients younger than 40

More information: Toriyama E, Nanashima A, Hayashi H, Abe K, Kinoshita N, Yuge S, Nagayasu T, Uetani M, Hayashi T. A case of intrahepatic clear cell cholangiocarcinoma. World J Gastroenterol 2010; 16(20): 2571-2576 www.wjgnet.com/1007-9327/full/v16/i20/2571.htm

add to favorites email to friend print save as pdf

Related Stories

Prognosis of intrahepatic cholangiocarcinoma

Jan 15, 2010

Incidence of intrahepatic cholangiocarcinoma (ICC) is increasing worldwide and its prognosis is very poor. Thus, further studies on its clinical characteristics for early detection and on surgical treatment for better prognosis ...

Gastric cancer with 3 pathological features

Sep 18, 2008

Primary carcinoma of the stomach is almost always adenocarcinoma or signet ring cell carcinoma and there are few reports of choriocarcinoma or neuroendocrine cell carcinoma. We report a patient with adenocarcinoma of the ...

Hepatitis B virus mutations may predict risk of liver cancer

Jul 02, 2009

Certain mutations in the DNA of the hepatitis B virus (HBV) are associated with the development of liver cancer and may help predict which patients with HBV infections are at increased risk of the disease, according to a ...

Recommended for you

Dog's epigenome gives clues to human cancer

1 hour ago

The bond between humans and dogs is strong and ancient. From being the protector of the first herds in a faithful pet, dogs and people share many aspects of life. The relationship between the two species ...

Study pinpoints microRNA tied to colon cancer tumor growth

17 hours ago

Researchers at the University of Minnesota have identified microRNAs that may cause colon polyps from turning cancerous. The finding could help physicians provide more specialized, and earlier, treatment before colon cancer ...

User comments : 0