Phosphorous in sodas and processed foods accelerates signs of aging, scientists say

Apr 26, 2010

Here's another reason to kick the soda habit. New research published online in the FASEB Journal shows that high levels of phosphates may add more "pop" to sodas and processed foods than once thought. That's because researchers found that the high levels of phosphates accelerate signs of aging. High phosphate levels may also increase the prevalence and severity of age-related complications, such as chronic kidney disease and cardiovascular calcification, and can also induce severe muscle and skin atrophy.

"Humans need a and keeping the balance of in the diet may be important for a healthy life and longevity," said M. Shawkat Razzaque, M.D., Ph.D., from the Department of Medicine, Infection and Immunity at the Harvard School of Dental Medicine. "Avoid phosphate toxicity and enjoy a healthy life."

To make this discovery, Razzaque and colleague examined the effects of high phosphate levels in three groups of mice. The first group of mice was missing a gene (klotho), which when absent, causes mice to have toxic levels of phosphate in their bodies. These mice lived 8 to 15 weeks. The second group of mice was missing the klotho gene and a second gene (NaPi2a), which when absent at the same time, substantially lowered the amount of phosphate in their bodies. These mice lived to 20 weeks. The third group of mice was like the second group (missing both the klotho and NaPi2a genes), except they were fed a high-phosphate diet. All of these mice died by 15 weeks, like those in the first group. This suggests that phosphate has toxic effects in mice, and may have a similar effect in other mammals, including humans.

"Soda is the caffeine delivery vehicle of choice for millions of people worldwide, but comes with phosphorous as a passenger" said Gerald Weissmann, M.D., Editor-in-Chief of the . "This research suggests that our phosphorous balance influences the , so don't tip it."

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More information: Mutsuko Ohnishi and M. Shawkat Razzaque. Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging. FASEB J. doi:10.1096/fj.09-152488

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NotAsleep
3 / 5 (1) Apr 26, 2010
So they determined the effects of a high-phosphorus diet in humans by genetically modifying mice? What happened to the tried and true method of having a control group? And why not just feed REGULAR mice a high phosphorus diet?

I hope the article is lacking in information rather than the test lacking in validity
theophys
5 / 5 (1) Apr 26, 2010
So...mice missing a gene that controls phosphorous levels end up with lethal amounts of phosphorous. Further more, having lethal amounts of phosphorous in the body significantly reduces the life span of mice. Thank you Havard School of Dental Medicine!

For your next experiment you can find out what effects lethal voltages across the heart have on gophers. I'm no dentist but my bet is that the gophers will have either a reduced life span or a reduced risk of getting gingivitus
eric_in_chicago
5 / 5 (1) Apr 26, 2010
its funny how since i have given up tv, i am less and less inclined to drink sody-pop, which i do very much enjoy. just thought of that...

also, and most importantly i have become acutley aware that i don't feel all that great when i get my caff kick from soda.

coffee makes me feel good, cola, not so great at all!

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