Substance in breast milk kills cancer cells

Apr 19, 2010
Microscope images that show HAMLET's interaction with biological membranes. Using a red, fluorescent substance that shows the location of HAMLET, the researchers can clearly demonstrate that it binds to the cell membrane of a tumor cell. Credit: University of Gothenburg

A substance found in breast milk can kill cancer cells, reveal studies carried out by researchers at Lund University and the University of Gothenburg, Sweden.

Although the special substance, known as HAMLET (Human Alpha-lactalbumin Made LEthal to ), was discovered in breast milk several years ago, it is only now that it has been possible to test it on humans. Patients with cancer of the bladder who were treated with the substance excreted dead in their urine after each treatment, which has given rise to hopes that it can be developed into medication for cancer care in the future.

Discovered by chance

HAMLET was discovered by chance when researchers were studying the antibacterial properties of breast milk. Further studies showed that HAMLET comprises a protein and a fatty acid that are both found naturally in . So far, however, it has not been proven that the HAMLET complex is spontaneously formed in the milk. It is speculated, however, that HAMLET can form in the acidic environment of the babies´ stomachs. Laboratory experiments have shown that HAMLET kills 40 different types of cancer, and the researchers are now going on to study its effect on , tumours in the mucous membranes and brain tumours. Importantly, HAMLET kills only cancer cells and does not affect healthy cells.

Studying the integration of the substance

Researchers at the University of Gothenburg are focusing on how HAMLET can be taken up into tumour cells. The researchers, Roger Karlsson, Maja Puchades and Ingela Lanekoff, are attempting to gain an in-depth understanding of how the substance interacts with cell membranes, and their findings were recently published in the prestigious journal PLoS One.

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THoKling
not rated yet Apr 19, 2010
Cancer cells are highly unstable compared to normal cells, so it's possible that normal cells suffering from a weakened condition may be susceptible to the veracity of HAMLET depending upon how it interacts with biological markers.

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