Bacterial phylotype alterations in irritable bowel syndrome

Jan 15, 2010

Irritable bowel syndrome (IBS) is a common gastrointestinal functional disorder that can greatly affect the patient's well being. Multiple interacting mechanisms, including alterations in the intestinal microbiota, are suspected to lie behind IBS aetiology.

A research article to be published on December 21, 2009 in the addresses this question. The research team from Finland quantified fourteen bacterial phylotypes which corresponded with of the gastrointestinal (GI) tract from faecal samples of IBS patients and healthy controls. In their study, assays for analyzing phylotype specific bacterial alterations in association to IBS were developed and applied.

They found a phylotype with 85% similarity to C. thermosuccinogenes was quantified in significantly different quantities among the diarrhoea-predominant (IBS-D) and control subjects, IBS-D and mixed symptom-subtype (IBS-M) subjects. A phylotype with 94% similarity to R. torques was more prevalent in IBS-D patients' intestinal microbiota than in that of control subjects. A phylotype with 93% similarity to R. torques was associated with control samples when compared with IBS-M. Additionally, a R. bromii-like phylotype was associated with constipation-predominant (IBS-C) patients in comparison to control subjects.

The researchers drew a conclusion that the detected altering phylotypes might be useful as targets in diagnostic, therapeutic and host-microbe interaction studies.

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More information: Lyra A, Rinttilä T, Nikkilä J, Krogius-Kurikka L, Kajander K, Malinen E, Mättö J, Mäkelä L, Palva A. Diarrhoea-predominant irritable bowel syndrome distinguishable by 16S rRNA gene phylotype quantification. World J Gastroenterol 2009; 15(47): 5936-5945 www.wjgnet.com/1007-9327/15/5936.asp

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