Sex-based prenatal brain differences found

Oct 23, 2009

Prenatal sex-based biological differences extend to genetic expression in cerebral cortices. The differences in question are probably associated with later divergences in how our brains develop. This is shown by a new study by Uppsala University researchers Elena Jazin and Björn Reinius, which has been published in the latest issue of the journal Molecular Psychiatry.

Professor Elena Jazin and doctoral student Björn Reinius at the Department of Physiology and Developmental Biology previously demonstrated that genetic expression in the cerebral cortices of human beings and other primates exhibits certain sex-based differences. It is presumed that these differences are very old and have survived the evolutionary process. The purpose of the new study was to determine whether they appear during the process of development or first upon the conclusion of that process. Identifying the initial genetic mechanisms that prompt the brain to develop in a female or male direction is a long-range research objective.

The Uppsala University researchers analysed data, on the basis of sex, from another extensive study of the prenatal human brain.

"The results show that many of the genes situated on the are expressed in various parts of the brain prior to birth and probably provide a developmental basis for the sex-based differences exhibited by adult brains," according to Elena Jazin.

More than a third of Y-chromosomal genes appear to be involved in sex-based human brain differentiation. Some of the genetic activity in question is evident in the adult brain, while other of it only appears at earlier stages of . It is yet unknown whether the differences in among female and male brains have any functional significance.

"The findings are consistent with other factors, such as environment, also playing a role in how we develop," emphasizes Elena Jazin.

Knowledge of the development of sex-based brain differences is of potential significance for the treatment of brain disturbances and diseases. A large number of psychiatric illnesses, including depression and autism, affect men and women differentially.

"Taking account of sex-based differences is crucial to the study of normal and abnormal brain activity," according to Elena Jazin.

More information: www.nature.com/mp/journal/v14/n11/index.html

Source: Uppsala University (news : web)

Explore further: Three of four California children with mental health needs don't get treatment

add to favorites email to friend print save as pdf

Related Stories

When It Comes to Brains, Size Matters

Jun 20, 2008

Findings of a three-year study by researchers at the University of California, Riverside and the University of Florida, Gainesville run counter to the popular belief that women have better language skills than men.

Visuospatial, verbal brain role studied

Jul 18, 2006

U.S. scientists say they've confirmed the theory men and women use different parts of their brains processing language and visuospatial information.

Genetic link to gender identity

Oct 30, 2008

In the largest ever genetic study of male to female transsexuals Australian researchers have found a significant genetic link between gender identity and a gene involved in testosterone action.

Recommended for you

A blood test for suicide?

1 hour ago

Johns Hopkins researchers say they have discovered a chemical alteration in a single human gene linked to stress reactions that, if confirmed in larger studies, could give doctors a simple blood test to reliably predict a ...

Could summer camp be the key to world peace?

16 hours ago

According to findings from a new study by University of Chicago Booth School of Business Professor Jane Risen, and Chicago Booth doctoral student Juliana Schroeder, it may at least be a start.

Gender disparities in cognition will not diminish

Jul 28, 2014

The study, published in the Proceedings of the National Academy of Science, investigated the extent to which improvements in living conditions and educational opportunities over a person's life affect cognitive abilities and th ...

Facial features are the key to first impressions

Jul 28, 2014

A new study by researchers in the Department of Psychology at the University of York shows that it is possible to accurately predict first impressions using measurements of physical features in everyday images of faces, such ...

User comments : 0