Ensuring integrity in clinical effectiveness research: Accentuate the negative

Sep 29, 2009

In an editorial published this week, the PLoS Medicine editors discuss how to maintain the integrity of the medical literature when publishing comparative effectiveness research (CER).

The U.S. government has allocated US$ 1.1 billion to fund CER, which will compare the benefits and harms of different approaches to medical care. As defined in a recent Institute of Medicine report, "the purpose of CER is to assist consumers, clinicians, purchasers, and policy makers to make informed decisions that will improve at both the individual and population levels."

The editorial points out that in order to serve this purpose reliably, reports of CER must be transparent in their methods and objectives, and researchers must refrain from "practices that distort the scientific evidence base—such as 'cherry picking' for publication only those studies describing a desired outcome, or 'fishing' from an ocean of possible analyses only those that might support favorable (but statistically invalid) conclusions

More information: The Editors (2009) Ensuring Integrity in Comparative Effectiveness Research: Accentuate the Negative. PLoS Med 6(9): e1000152. doi:10.1371/journal.pmed.1000152

Source: Public Library of Science (news : web)

Explore further: New research demonstrates benefits of national and international device registries

add to favorites email to friend print save as pdf

Related Stories

Homelessness is not just a housing problem

Dec 23, 2008

The editorial in this month's PLoS Medicine examines how the health needs of the homeless are underrepresented in the medical literature, leading to the failure of health and social systems to address them. At a time when c ...

Half of trials supporting FDA applications go unpublished

Sep 23, 2008

Over half of all supporting trials for FDA-approved drugs remained unpublished 5 years after approval, says new research published in this week's PLoS Medicine. The most important trials determining efficacy, and those with s ...

Considering usual medical care in clinical trial design

Sep 29, 2009

In this week's PLoS Medicine, Liza Dawson (National Institutes of Health) and colleagues discuss the scientific and ethical issues associated with choosing clinical trial designs when there is no consensus on what consti ...

Recommended for you

New approach to particle therapy dosimetry

Dec 19, 2014

Researchers at the National Physical Laboratory (NPL), in collaboration with EMRP partners, are working towards a universal approach to particle beam therapy dosimetry.

Supplement maker admits lying about ingredients

Dec 17, 2014

Federal prosecutors say the owner and president of a dietary supplement company has admitted his role in the sale of diluted and adulterated dietary ingredients and supplements sold by his company.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.