Infiltrating blood-derived macrophages play a role in recovery from spinal cord injury in mice

Jul 28, 2009

Although macrophages are known as essential players in wound healing, their contribution to recovery from spinal cord injury is a subject of debate.

Using a mouse model of spinal injury, Michal Schwartz and colleagues from the Weizmann institute of Science, Rehovot, Israel tested the effect of macrophages on the recovery process after injury and demonstrate an important anti-inflammatory role for a subset of infiltrating monocyte-derived macrophages that is dependent upon their expression of the anti-inflammatory molecule interleukin-10.

These results suggest that this subset of macrophages may have a beneficial effect on injuries.

More information: Shechter R, London A, Varol C, Raposo C, Cusimano M, et al. (2009) Infiltrating Blood-Derived Macrophages Are Vital Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice. PLoS Med 6(7): e1000113. doi:10.1371/journal.pmed.1000113, http://medicine.plosjournals.org/perlserv/?request=get-document&doi=1000113

Source: Public Library of Science (news : web)

Explore further: Two Michigan high school students develop screening tools to detect lung and heart disease

add to favorites email to friend print save as pdf

Related Stories

Enabling nerve regeneration means evicting the cleanup crew

Feb 28, 2007

Macrophages are the immune cells that engulf and destroy the debris of damaged tissue to enable the healing process to begin. Their presence at the scene of damage is critical, but once their task is complete, it is just ...

Stem cells used to reverse paralysis in animals

Jan 28, 2009

A new study has found that transplantation of stem cells from the lining of the spinal cord, called ependymal stem cells, reverses paralysis associated with spinal cord injuries in laboratory tests. The findings show that ...

Recommended for you

Neutralising antibodies for safer organ transplants

15 hours ago

Serious complications can arise following kidney transplants. If dialysis is required within the first seven days, then the transplanted organ is said to have a Delayed Graft Function (DGF), and essentially ...

User comments : 0