Nasal Spray May End Dental Needle Injections for Upper Teeth Repair

Feb 17, 2009

(PhysOrg.com) -- A nasal spray shown to numb the upper jaw is set to be tested in an FDA Phase 3 trial, which will assess the spray's effectiveness compared to the current "gold standard" treatment -- painful anesthesia injections.

"A successful trial of this new dental anesthetic will change dental technology worldwide," said Sebastian Ciancio, D.D.S., University at Buffalo SUNY Distinguished Service Professor and chair of the Department of Periodontics and Endodontics.

Ciancio directed the Phase 2 trial and will coordinate the Phase 3 trial. Between 6 and10 million dental needle injections are given daily, according to Ciancio.

Results of the FDA Phase 2 trial, conducted in 48 subjects at the UB School of Dental Medicine, showed that the spray appears to be safe and effective.

The Phase 3 trial will be carried out later in 2009 at the UB dental school and other clinical sites. Ciancio said that if the Phase 3 trial is successful, it may mean the end of injections for any dental work performed on the upper teeth.

Ciancio and colleagues conducted the initial preliminary dental studies using the nasal spray, which is being developed by St. Renatus, LLC, based in Fort Collins, Colo.

The nasal spray formula being tested is related to a drug used by ear, nose and throat physicians when they operate on the nose. Patients who received this anesthetic reported that their upper teeth felt numb, sparking interest in using the anesthetic for dental procedures. The spray is effective only on the upper teeth.

Provided by University at Buffalo

Explore further: Risks of taking paracetamol long-term may have been underestimated by clinicians

add to favorites email to friend print save as pdf

Related Stories

Evolving robot brains

6 hours ago

Researchers are using the principles of Darwinian evolution to develop robot brains that can navigate mazes, identify and catch falling objects, and work as a group to determine in which order they should ...

Facebook fends off telecom firms' complaints

6 hours ago

Facebook founder Mark Zuckerberg fended off complaints on Monday that the hugely popular social network was getting a free ride out of telecom operators who host its service on smartphones.

Scientists find clues to cancer drug failure

6 hours ago

Cancer patients fear the possibility that one day their cells might start rendering many different chemotherapy regimens ineffective. This phenomenon, called multidrug resistance, leads to tumors that defy ...

Glass coating improves battery performance

6 hours ago

Lithium-sulfur batteries have been a hot topic in battery research because of their ability to produce up to 10 times more energy than conventional batteries, which means they hold great promise for applications ...

Recommended for you

Anticholinergic drugs linked to risk for pneumonia in elderly

16 hours ago

Taking commonly used medications with anticholinergic effects is associated with a significantly higher risk for developing pneumonia in a study of more than 3,000 older Group Health patients living in the community—not ...

Drug research and development more efficient than expected

Feb 27, 2015

Drug R&D costs have increased substantially in recent decades, while the number of new drugs has remained fairly constant, leading to concerns about the sustainability of drug R&D and question about the factors that could ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.