Bone marrow transplant patients may benefit from new immune research

Feb 11, 2009

Bone marrow transplant (BMT) researchers at The Medical College of Wisconsin Cancer Center in Milwaukee may have found a mechanism that could preserve the leukemia-killing effects of a transplant graft, while limiting the damage donor immune cells might do to the recipient host's vital organs.

"Our results suggest that targeting of interleukin 23, (IL-23), an immune substance secreted by donor marrow cells, may be a viable way to limit graft-versus-host-disease without limiting graft-versus-leukemia activity," says lead researcher Rupali Das, Ph.D.

The study was presented at the national BMT Tandem Meetings in Tampa, Fla., Feb. 11, 2009, and was among those receiving the highest scores from the abstract review committee. Dr. Das is a postdoctoral fellow in pediatric hematology/oncology at the Medical College in the laboratory of William R. Drobyski, M.D., professor of medicine in neoplastic diseases, and principal investigator of this study. Dr. Drobyski practices at Froedtert Hospital.

In a recent study, the researchers found that donor mice with marrow cells incapable of producing IL-23, provided protection from graft-versus-host damage to the recipient's colon, but not to other organs.

They then conducted studies in which mice with leukemia received T cells from the marrow and spleen of IL-23-deficient donor mice. The recipient mice not only had longer survival times than those receiving T-cells from IL-23-producing mice, but also showed no evidence of leukemia. Mice transplanted with T cells capable of producing IL-23 all died of graft versus host disease.

Source: Medical College of Wisconsin

Explore further: West Africa's Ebola outbreak prompts changes in I.Coast cuisine

add to favorites email to friend print save as pdf

Related Stories

Hormone's crucial role in 2 anemic blood disorders

Nov 23, 2010

A hormone made by the body may be a potential therapeutic tool for the treatment of two anemic blood disorders -- beta-thalassemia and hemochromatosis. The new research was led by scientists at Weill Cornell Medical College ...

Researchers crack rare disease's code with technology

May 11, 2010

In work that offers hope to every doctor who ever refrigerated DNA from a patient with a baffling disease, government researchers have read the genes of two families afflicted with a rare illness that kills male infants and ...

Novel nanoparticles prevent radiation damage (w/ Video)

Apr 26, 2010

Tiny, melanin-covered nanoparticles may protect bone marrow from the harmful effects of radiation therapy, according to scientists at Albert Einstein College of Medicine of Yeshiva University who successfully tested the strategy ...

Recommended for you

Two expats die of MERS in Saudi commercial hub

21 hours ago

Two foreigners died of MERS in the Saudi city of Jeddah, the health ministry said Saturday, as fears rise over the spreading respiratory virus in the kingdom's commercial hub.

UAE reports 12 new cases of MERS

21 hours ago

Health authorities in the United Arab Emirates have announced 12 new cases of infection by the MERS coronavirus, but insisted the patients would be cured within two weeks.

Filipino tests negative for Middle East virus

Apr 19, 2014

A Filipino nurse who tested positive for the Middle East virus has been found free of infection in a subsequent examination after he returned home, Philippine health officials said Saturday.

User comments : 0

More news stories

Cancer stem cells linked to drug resistance

Most drugs used to treat lung, breast and pancreatic cancers also promote drug-resistance and ultimately spur tumor growth. Researchers at the University of California, San Diego School of Medicine have discovered ...

Poll: Big Bang a big question for most Americans

Few Americans question that smoking causes cancer. But they have more skepticism than confidence in global warming, the age of the Earth and evolution and have the most trouble believing a Big Bang created the universe 13.8 ...

Making graphene in your kitchen

Graphene has been touted as a wonder material—the world's thinnest substance, but super-strong. Now scientists say it is so easy to make you could produce some in your kitchen.