Scientists uncover mechanism for dental pain

Jan 08, 2009

Researchers at Oregon Health & Science University's School of Dentistry have discovered a novel function of the peptide known as Nerve Growth Factor (NGF) in the development of the trigeminal nerve. The trigeminal nerve provides the signaling pathway for periodontal pain, dental surgical pain, and pain associated with temporomandibular disorder, trigeminal neuralgia, migraine, and other neuropathic and inflammatory conditions.

The study is posted online (www.neuropeptidesjournal.com/article/S0143-4179(08)00110-8/abstract) in the journal Neuropeptides and will appear in print issues of that journal in early 2009.

Working with researchers in the dental school departments of Endodontology and Integrative Biosciences, second-year endodontology resident and lead author of the study, Leila Tarsa, D.D.S., M.S., found a new mechanism involved in establishing junctions - known as synapses - between trigeminal nerve cells. Nerve cells communicate with one another through chemicals called transmitters that are released at synapses. The transmitter release from nerve cells endings is possible only if aided by several molecules that are critical for proper function of the synapse. Tarsa's research shows that NGF promotes transport of one of the molecules (called synaptophysin) from the nerve cell body to its ending.

"The data indicate that NGF participates in formation of neuronal connections in the trigeminal system," said Agnieszka Balkowiec, M.D., Ph.D., OHSU School of Dentistry assistant professor of integrative biosciences and OHSU School of Medicine adjunct assistant professor of physiology and pharmacology, who is the senior author of the study and whose lab hosted the research. "This study has broad implications for trigeminal nerve regeneration."

On the web: www.ohsu.edu/sod

Source: Oregon Health & Science University

Explore further: Nerve cells and blood vessels in eye 'talk' to prevent disease, study finds

Related Stories

Nepal quake: Nearly 1,400 dead, Everest shaken (Update)

7 hours ago

Tens of thousands of people were spending the night in the open under a chilly and thunderous sky after a powerful earthquake devastated Nepal on Saturday, killing nearly 1,400, collapsing modern houses and ...

Russian hackers read Obama emails, report says

7 hours ago

Emails to and from President Barack Obama were read by Russian hackers last year in a breach of the White House's unclassified computer system, The New York Times said Saturday.

Supermarkets welcome cold-comfort edge of F1 aerofoils

12 hours ago

UK-based Williams Advanced Engineering, the technology and engineering services business of the Williams Group, has collaborated with UK-based Aerofoil Energy to develop an aerodynamic device that can reduce ...

Public boarding school—the way to solve educational ills?

15 hours ago

Buffalo's chronically struggling school system is considering an idea gaining momentum in other cities: public boarding schools that put round-the-clock attention on students and away from such daunting problems as poverty, ...

Recommended for you

New material for creating artificial blood vessels

6 hours ago

Blocked blood vessels can quickly become dangerous. It is often necessary to replace a blood vessel – either by another vessel taken from the body or even by artificial vascular prostheses. Together, Vienna ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.