Pneumococcal vaccine does not appear to protect against pneumonia

Jan 05, 2009

Commonly used pneumococcal polysaccharide vaccines do not appear to be effective for preventing pneumonia, found a study by a team of researchers from Switzerland and the United Kingdom.

In many industrialized countries, polysaccharide pneumococcal vaccines (PPVs) are currently recommended to help prevent pneumococcal disease in people aged 65 and over and for younger people with increased risk due to conditions like HIV. Studies have shown conflicting results regarding the efficacy of PPV.

The study, a systematic review and meta-analysis, looked at 22 clinical trials, reviews and meta-analyses and more than 100,000 participants from countries in North America as well as India, Africa, Latin America and the Caribbean. Unlike other similar studies the authors examined the reasons why different clinical trials produced different results. They found that the quality of the studies substantially affected the results. When only high quality trials were included, there was no evidence that PPVs could prevent pneumonia. The study adds to the ongoing debate around effectiveness of the vaccine.

"Policy makers may therefore wish to reconsider their current recommendations for PPV, especially where routine pneumococcal conjugate immunization has been introduced," conclude Dr. Matthias Egger from the University of Bern, Switzerland and coauthors.

However, in a related commentary www.cmaj.ca/press/pg18.pdf>, Dr. Ross Andrews and coauthor from the Menzies School of Health Research, Darwin, Australia state that the researchers' conclusions exceed the evidence presented. They caution that there should be no change in vaccine policy in countries that recommend PPV to prevent invasive pneumococcal disease.

Paper: www.cmaj.ca/press/pg48.pdf>

Source: Canadian Medical Association Journal

Explore further: FDA: generic copaxone approved for multiple sclerosis

Related Stories

Hackers attack Belgian press group, second in days

17 hours ago

Hackers attacked one of Belgium's top newspaper publishers on Sunday just days after Tunisian Islamist militants took control of a regional government portal to denounce US counter-terror operations.

An exoplanet with an infernal atmosphere

17 hours ago

As part of the PlanetS National Centre of Competence in Research (NCCR), astronomers from the Universities of Geneva (UNIGE) and Bern, Switzerland, have come to measure the temperature of the atmosphere of ...

West Coast sardine collapse leads to fishing closure

1 hour ago

Fisheries managers have decided to call off the West Coast sardine fishing season that starts in July because of rapidly dwindling numbers, hoping to save an iconic industry from the kind of collapse that hit in the 1940s ...

Recommended for you

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.