Fruit fly research may lead to better understanding of human heart disease

Dec 02, 2008

Researchers at the Burnham Institute for Medical Research (Burnham) have shown in both fruit flies and humans that genes involved in embryonic heart development are also integral to adult heart function. The study, led by Rolf Bodmer, Ph.D., was published in Proceedings of National Academy of Sciences.

Dr. Bodmer's lab has discovered that in the fruit fly Drosophila, interactions between cardiac nmr genes (TBX20 in humans) and other transcription factors, are involved in regulating cardiac performance, rhythm and heart muscle structure. TBX20, along with other congenital heart disease genes, has been previously shown to be critical to the development of the embryonic heart first in flies and subsequently in mouse models.

However, this study is the first indication that nmr/TBX20 also plays a role in adult heart function. These genes are highly conserved from flies to humans and Bodmer's research showed that some human individuals with structural congenital heart abnormalities, as well as problems with heart function, including arrhythmias and heart failure, also exhibited TBX20 mutations.

"These studies demonstrate that Drosophila has potential as a model system for exploring the genetics underlying human heart disease and for identifying new candidate genes that potentially cause heart disease," said Dr. Bodmer.

To make the connection between human and Drosophila heart malfunction, human subjects with structural congenital heart disease, as well as heart muscle dysfunction were examined. In 96 human subjects with clinical evidence of dilated cardiomyopathy (this causes a weakened heart that cannot pump blood efficiently), DNA analysis identified three different variants of the gene TBX20, suggesting TBX20 may be involved in the development of cardiomyopathy. In addition, TBX20 variants were identified in four children with atrial septal defects.

Source: Burnham Institute

Explore further: Study demonstrates potential of rapid whole-genome sequencing in critically ill infants

Related Stories

Claims about the decline of the West are 'exaggerated'

5 hours ago

A new paper by Oxford researchers argues that some countries in Western Europe, and the USA, Canada, Australia and New Zealand now have birth rates that are now relatively close to replacement, that the underlying trend in ...

Norway tests out 'animal rights cops'

6 hours ago

Norwegian police is creating a unit to investigate cruelty to animals, the government said Monday, arguing that those who hurt animals often harm people too.

Recommended for you

New breast cancer gene identified

13 hours ago

A new breast cancer gene has been identified in a study led by Women's College Hospital (WCH) researcher Dr. Mohammad Akbari, who is also an assistant professor with the Dalla Lana School of Public Health ...

Researchers bring order to big data of human biology

13 hours ago

A multi-year study led by researchers from the Simons Center for Data Analysis (SCDA) and major universities and medical schools has broken substantial new ground, establishing how genes work together within ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.