If metastasectomy should be performed before other treatments

Oct 31, 2008

Primary HCC is a major cancer related to HBV viral infection in Asian countries, including Japan. Recently, the primary liver cancers are successfully treated by surgical resection including liver transplantation and non-surgical locoregional therapy.

Although not frequently, extrahepatic spread to the lung, so called lung metastasis from liver cancer is a dilemma, because it may be believed that diseases are very advanced and too late in being adequately treated. It is partly true that most of the patients with lung metastasis from liver cancer did not survive for more than 1 year. However, surgical resection has gained the benefit of better survival in a selected group. It is not well understood regarding when and how to undergo surgery for lung metastasis. Although small in numbers, successful results after collaborative treatments for lung metastasis from liver cancers were achieved.

A research article to be published on October 7, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Professor. Moon from Kangnam St. Mary Hospital, the Catholic University of Korea, consists of thoracic surgeons, liver physicians, and liver surgeons. For 8 years, the researchers studied 23 patients with liver cancer and concurrent or subsequent lung lesions, who underwent lung surgery with collaborative guidelines. After lung surgery, the treatment plans had to be changed according to pathology-matched basis. With true lung metastasis, 16 patients were observed (the longest one being more than 8 years), and were analyzed for survival and clinical prognostic factors.

The 1- and 5-year survival rates after the lung surgery were 56% and 26%, respectively, most of whom otherwise would die within one year without lung surgery. Although statistical power is weak due to small numbers, new prognostic factor was identified: patients who underwent liver transplantation and developed lung metastasis, survived longer after lung surgery. This message suggests that liver transplantation is the standard for treatment of liver cancer and guarantees longer survival, even in case of lung metastasis.

Source: World Journal of Gastroenterology

Explore further: US cautiously optimistic after no new Ebola in 5 days

add to favorites email to friend print save as pdf

Related Stories

A microchip for metastasis

Feb 06, 2014

Nearly 70 percent of patients with advanced breast cancer experience skeletal metastasis, in which cancer cells migrate from a primary tumor into bone—a painful development that can cause fractures and ...

Early indicators of lung cancer probed in new study

Jun 04, 2013

(Phys.org) —Many of the critical processes underlying cancer formation and eventual metastasis to other organs remain mysterious. In the quest for earlier diagnoses and more effective treatment, intensive ...

Recommended for you

US cautiously optimistic after no new Ebola in 5 days

1 hour ago

With no new Ebola cases in five days, US authorities were cautious but hopeful Monday that the virus has been contained in the United States after a flawed response revealed shortcomings in the system.

Nigeria declared Ebola-free in 'spectacular success'

1 hour ago

Nigeria was declared Ebola-free on Monday in a "spectacular success" in the battle to contain the spread of a virus which is devastating Guinea, Sierra Leone and Liberia where more than 4,500 people have died.

EU says 'increased' effort needed to tackle Ebola

2 hours ago

European Union foreign ministers agreed Monday to step up efforts to contain Ebola to prevent it becoming a global threat, including ensuring proper care for international health workers.

User comments : 0