If metastasectomy should be performed before other treatments

Oct 31, 2008

Primary HCC is a major cancer related to HBV viral infection in Asian countries, including Japan. Recently, the primary liver cancers are successfully treated by surgical resection including liver transplantation and non-surgical locoregional therapy.

Although not frequently, extrahepatic spread to the lung, so called lung metastasis from liver cancer is a dilemma, because it may be believed that diseases are very advanced and too late in being adequately treated. It is partly true that most of the patients with lung metastasis from liver cancer did not survive for more than 1 year. However, surgical resection has gained the benefit of better survival in a selected group. It is not well understood regarding when and how to undergo surgery for lung metastasis. Although small in numbers, successful results after collaborative treatments for lung metastasis from liver cancers were achieved.

A research article to be published on October 7, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Professor. Moon from Kangnam St. Mary Hospital, the Catholic University of Korea, consists of thoracic surgeons, liver physicians, and liver surgeons. For 8 years, the researchers studied 23 patients with liver cancer and concurrent or subsequent lung lesions, who underwent lung surgery with collaborative guidelines. After lung surgery, the treatment plans had to be changed according to pathology-matched basis. With true lung metastasis, 16 patients were observed (the longest one being more than 8 years), and were analyzed for survival and clinical prognostic factors.

The 1- and 5-year survival rates after the lung surgery were 56% and 26%, respectively, most of whom otherwise would die within one year without lung surgery. Although statistical power is weak due to small numbers, new prognostic factor was identified: patients who underwent liver transplantation and developed lung metastasis, survived longer after lung surgery. This message suggests that liver transplantation is the standard for treatment of liver cancer and guarantees longer survival, even in case of lung metastasis.

Source: World Journal of Gastroenterology

Explore further: Study IDs risk factors for severe hidradenitis suppurativa

add to favorites email to friend print save as pdf

Related Stories

A microchip for metastasis

Feb 06, 2014

Nearly 70 percent of patients with advanced breast cancer experience skeletal metastasis, in which cancer cells migrate from a primary tumor into bone—a painful development that can cause fractures and ...

Early indicators of lung cancer probed in new study

Jun 04, 2013

(Phys.org) —Many of the critical processes underlying cancer formation and eventual metastasis to other organs remain mysterious. In the quest for earlier diagnoses and more effective treatment, intensive ...

Recommended for you

Ivory Coast closes borders with Ebola-hit neighbours

3 hours ago

The Ivory Coast has closed its borders with Ebola-hit Guinea and Liberia in a bid to protect citizens against an epidemic that has killed 1,427 people across West Africa, the prime minister said Saturday.

How the world is underestimating Ebola: WHO

12 hours ago

The Ebola epidemic tearing through western Africa is by far the deadliest known outbreak of the disease, yet the magnitude of the spread is believed to be severely underestimated.

Last Ebola-free region of Liberia falls to virus

12 hours ago

Every region of Liberia has now been hit by Ebola, officials said Friday, as the World Health Organization warned the fight against the worst-ever outbreak of the killer disease would take months.

Ebola death toll rises to 1,427: WHO

22 hours ago

The death toll from the Ebola outbreak sweeping through west African countries has risen to 1,427 out of more than 2,600 cases, the World Health Organization said Friday.

User comments : 0