Stem-cell sentry sounds the alarm to maintain balance between cancer and aging

Oct 15, 2008

(PhysOrg.com) -- Like a sentry guarding the castle walls, a molecular messenger inside adult stem cells sounds the alarm when it senses hazards that could allow the invasion of an insidious enemy: Cancer. The alarm bell halts the process of cell division in its tracks, preventing an error that could lead to runaway cell division and eventually, tumor formation.

"Our work suggests that to be able to prevent abnormal cell proliferation, which could lead to cancer, stem cells developed this self-checking system, what we're calling a checkpoint," said Yukiko Yamashita of the University of Michigan's Life Sciences Institute.

"And if it looks like the cell is going to divide in the wrong way, the checkpoint senses there's a problem and sends the signal: 'Don't divide! Don't divide!'" said Yamashita, a research assistant professor of life sciences and an assistant professor of cell and developmental biology at the U-M Medical School.

If everything looks OK, the checkpoint allows adult stem-cell division to proceed, providing new cells to replace damaged and worn-out tissues.

Yamashita and her colleagues have not yet identified the molecules that form the checkpoint mechanism. But they've seen it at work in adult stem cells of the fruit-fly testes, so-called germ-line stem cells.

"Aging is too few divisions and cancer is too many divisions, and people have long speculated that some process controls the balance between them," Yamashita said. "We may have found the mechanism that maintains the delicate balance between over-proliferation---which can lead to cancer---and aging."

The team's findings will be published Oct. 15 in the online version of the journal Nature.

If humans possess a similar checkpoint system and if researchers could someday harness it, they could fine-tune the rate of cellular division to control tumor development as well as tissue aging. But Yamashita stressed that no mammal studies of the checkpoint have been undertaken, so talk of potential human applications is highly speculative.

In fruit flies, the checkpoint monitors germ-line stem cells as they're about to divide. It can sense problems that would derail the division process, which is called mitosis.

Under normal conditions, adult stem-cell division creates one new stem cell and one cell committed to develop into a specific tissue type – such as a skin cell, a blood cell or, in this case, a sperm cell. That form of mitosis is called asymmetric division, and it's exactly what stem cells need to maintain a healthy balance between uncommitted and committed cells.

Cell division is controlled in part by the location of a pair of cellular components called centrosomes. They provide the framework that helps direct how chromosomes are distributed between daughter cells during mitosis.

Normally, centrosomes in a dividing stem cell remain perpendicular to an adjoining messenger cell called the hub. Yamashita and her colleagues found that improper orientation of the centrosomes disrupts the mitotic machinery, steering it on a course toward stem-cell over-proliferation and cancer.

The checkpoint mechanism senses when centrosomes are misaligned, then sounds the alarm that stops cell division.

By preventing faulty cell division, the checkpoint helps ward off cancer. But a balance must be struck: If the checkpoint mechanism slows cell division to a trickle, the resulting shortage of new cells will accelerate tissue aging.

"It's a double-edged sword, and both outcomes are bad," she said. "One path leads to cancer and the other leads to aging. And we haven't found a way to avoid aging without getting cancer."

Provided by University of Michigan

Explore further: Biologists reprogram skin cells to mimic rare disease

add to favorites email to friend print save as pdf

Related Stories

Hibernating frogs give clues to halting muscle wastage

Jul 01, 2014

Scientists at the University of Queensland, Australia, have identified key genes that help burrowing frogs avoid muscle wastage whilst they are dormant. These genetic insights could help prevent muscle atrophy ...

Puzzling question in bacterial immune system answered

Jan 29, 2014

(Phys.org) —A central question has been answered regarding a protein that plays an essential role in the bacterial immune system and is fast becoming a valuable tool for genetic engineering. A team of researchers ...

Recommended for you

Biologists reprogram skin cells to mimic rare disease

3 hours ago

Johns Hopkins stem cell biologists have found a way to reprogram a patient's skin cells into cells that mimic and display many biological features of a rare genetic disorder called familial dysautonomia. ...

Student seeks to improve pneumonia vaccines

Aug 20, 2014

Almost a million Americans fall ill with pneumonia each year. Nearly half of these cases require hospitalization, and 5-7 percent are fatal. Current vaccines provide protection against some strains of the ...

Seabed solution for cold sores

Aug 20, 2014

The blue blood of abalone, a seabed delicacy could be used to combat common cold sores and related herpes virus following breakthrough research at the University of Sydney.

User comments : 1

Adjust slider to filter visible comments by rank

Display comments: newest first

E_L_Earnhardt
not rated yet Oct 16, 2008
"Centrosomes", aligned with, or amplifying signals from the mitochondria, sound like an electronic "bias" system. If you can read the "bias" in electron volts you might predict the action or affect the outcome! Good work!