Retina transplants show promise in patients with retinal degeneration

Jul 10, 2008

Preliminary research shows encouraging results with transplantation of retinal cells in patients with blindness caused by retinitis pigmentosa (RP) and age-related macular degeneration (AMD), according to a report in the August issue of American Journal of Ophthalmology.

In the FDA-monitored study, Dr. Norman D. Radtke of University of Louisville, Ky., lead author of the study and colleagues performed the experimental transplant procedure in ten patients with vision loss resulting from retinal degeneration: six patients with RP and four with the "dry" form of AMD. Although they have different causes, both RP and AMD lead to destruction of the light-receiving (photoreceptor) cells of the retina. There is currently no effective treatment for recovery of visual loss from either condition.

All patients underwent transplantation of fetal retinal cells. The cells were implanted along with their attached retinal pigment epithelium, which plays a key role in nourishing the photoreceptor cells. The concept behind the experimental procedure was that the new cells would grow to replace the damaged photoreceptor cells, connecting to the patient's remaining retina.

Follow-up testing showed visual improvements in seven of the ten patients: three of the patients with RP and all four patients with AMD. Although vision remained in the "legally blind" range for all patients, the gains in vision were significant and measurable.

"This clinical evidence shows the promise of our method to alter progressive vision loss due to incurable degenerative diseases of the retina," comments Dr. Radtke.

In one patient with RP, the visual improvement was still present up to six years after surgery, while vision in the opposite (untreated) eye continued to deteriorate. In the same patient, specialized tests showed a 27 percent increase in light sensitivity in the treated eye.

There were no problems with rejection of the transplants by the patients' immune systems, despite the lack of a perfect immunological match between the transplant donors and recipients. This likely reflected the special "immunologic protection" of tissues within the eye. Two patients also had improved vision in the untreated eyes. The reason for this unexpected result is unknown, but may involve some effect of transplantation on the immune system.

The experimental transplant procedure was designed on the basis of animal studies showing that transplantation of retinal cells can lead to the development of new retinal tissues. Previous "phase I" studies established the safety of the procedure. The new "phase II" trial provides the first evidence of improved vision—the first treatment of any type to restore lost vision in patients with RP or AMD.

Much further research will be needed to determine the potential for retinal transplantation to improve vision in patients with these diseases. "Retinal implants that combine retina and retinal pigment epithelium demonstrated an apparent ability to integrate with host retinas and to re-establish the visual pathways interrupted by disease," adds Dr. Radtke. "What we have learned will help us to refine this method and obtain further evidence that retinal implants may be a viable therapy for retinal degenerative disease."

Source: Elsevier

Explore further: S.Korea detects second foot-and-mouth case

add to favorites email to friend print save as pdf

Related Stories

Medical advances turn science fiction into science fact

Jul 18, 2014

Exoskeletons helping the paralysed to walk, tiny maggot-inspired devices gnawing at brain tumours, machines working tirelessly as hospital helpers: in many respects, the future of medicine is already here.

New PRA gene identified in Phalenes and Papillons

Aug 29, 2013

Finnish researchers have identified a genetic mutation causing progressive retinal atrophy (PRA) in the Phalene and Papillon dog breeds. PRA is one of the most common causes of blindness in dogs and in human. ...

Recommended for you

S.Korea detects second foot-and-mouth case

26 minutes ago

South Korea on Monday reported its second case of foot-and-mouth disease in less than a week, triggering fearful memories of a devastating 2011 outbreak that forced the culling of millions of livestock.

Ebola kills Liberian doctor, 2 Americans infected

56 minutes ago

(AP)—One of Liberia's most high-profile doctors has died of Ebola, officials said Sunday, and an American physician was being treated for the deadly virus, highlighting the risks facing health workers trying ...

Hepatitis C virus genotype 1 is most prevalent worldwide

1 hour ago

In one of the largest prevalence studies to date, researchers from the U.K. provide national, regional, and global genotype prevalence estimates for the hepatitis C virus (HCV). Findings published in Hepatology, a journa ...

1 in 3000 blood donors in England infected with hepatitis E

1 hour ago

The first systematic analysis of hepatitis E virus (HEV) transmission by blood components indicates that about 1 in 3000 donors in England have HEV in their plasma. The findings, published in The Lancet, suggest that around ...

Biologic treatments for RA carry similar infection risk

1 hour ago

(HealthDay)—The risk of hospitalized bacterial infections in older rheumatoid arthritis (RA) patients is similar for rituximab or abatacept compared to etanercept, although it is higher for infliximab, ...

New oral drug regimens cure hardest-to-treat hepatitis C

1 hour ago

Two new pill-only antiviral drug regimens could provide shorter, more effective treatment options with fewer side effects for the majority of patients infected with hepatitis C, even those most difficult to treat, according ...

User comments : 0