Personal benefit, helping others motivate clinical trial participants

Jun 23, 2008

Most HIV-infected individuals participating in a clinical trial hope to benefit personally from the research but also understand they are contributing to society, according to a report in the June 23 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

Although there is a growing body of data explaining why individuals enroll in clinical trials, little research has been conducted regarding their motivation for ongoing participation, according to background information in the article. "Why do patient participants, especially those randomized to a control group, continue to accept the added risks and burdens, e.g., additional clinic visits and extra research procedures, that clinical research places on them?" the authors write. "Answering this question is especially important given the view that clinical research inappropriately exploits patient participants by exposing them to added risks and burdens for the benefit of others."

David Wendler, Ph.D., and colleagues at the Department of Bioethics, National Institutes of Health Clinical Center, reported group results of a survey of participants in the Evaluation of Subcutaneous Proleukin (Interleukin-2) in a Randomized International Trial (ESPRIT) study. ESPRIT is a phase 3 trial comparing antiretroviral medications alone to antiretroviral medications plus interleukin 2 (IL-2), a protein associated with the immune system. HIV-infected patients from Argentina, Brazil and Thailand who had been enrolled in the study for at least six months responded to questions regarding their motivations and experiences.

Of the 582 participants who responded to the follow-up survey, 292 were in the treatment group receiving IL-2 and 290 were in the group receiving antiretroviral medication alone. Participants were asked to choose from a list of 12 reasons why they continued to participate in the trial. "More than 80 percent indicated that the opportunity to obtain medical or personal benefit and the opportunity to help others were very important reasons for continuing to participate," the authors write. "Also, 90 percent believed they were making an important contribution to society, and 84 percent expressed pride in helping to advance scientific knowledge."

The findings suggest that patients can have multiple reasons for continuing to participate in clinical research. "Most importantly, the fact that respondents were motivated to obtain treatment for a life-threatening illness did not preclude them from being motivated to help others through their participation in the ESPRIT study as well," the authors conclude.

"These findings reveal that it is possible to conduct clinical research in developing countries without exploiting patient participants' failure to understand that they are participating in research and without exploiting their need for medical treatment to get them to contribute to goals that they do not endorse."

Source: JAMA and Archives Journals

Explore further: Penis transplant offers hope to victims of botched circumcisions

Related Stories

Google big Android Wear update adds functions, fun

1 hour ago

Android Wear's Monday announcement of new features is drawing many compliments from those watching out for what's next in making a smartwatch purchase. The new attractions include the lightness of wearing ...

Data deluge: MLB rolls out Statcast analytics on Tuesday

3 hours ago

Which outfielder sprints the fastest and runs the longest to snag line drives into the gap? Which shortstop is best at throwing from the grass to nip the runner at first? Which catcher gets the ball to second ...

Recommended for you

Game shows mosquito's-eye view of malaria

Apr 24, 2015

A new game about the life cycle of malaria that can be played on Android smartphones has been created by an Oxford University developer, based on malaria research at the University's Nuffield Department of ...

DMV program can generate additional organ donors

Apr 23, 2015

(HealthDay)—A brief, web-based training program for department of motor vehicles (DMV) employees that educates them about organ and tissue donation can increase the likelihood of customers registering as ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.