Weight loss after gastric bypass surgery may protect against infection and cancer

Jun 17, 2008

Another health benefit of bariatric weight-loss surgery may be a heightened immune defense against cancer and infections, a new study suggests. The results will be presented at The Endocrine Society's 90th Annual Meeting in San Francisco.

"Obesity is related to a higher rate of infections and some types of cancer," said a study coauthor, Alfredo Halpern, PhD, of the University of São Paulo, Brazil. "Nevertheless, there are only a few published studies evaluating the immune function in severely obese patients and the effect of surgery-induced weight loss on these parameters."

Halpern and his co-workers therefore studied the effect of weight loss on immune function in 28 morbidly obese patients who had traditional "stomach-stapling" (Roux-en-Y) gastric bypass surgery. The 20 women and eight men lost an average of 78.5 pounds 6 months after gastric bypass. This operation permanently reduces the size of the stomach and bypasses part of the intestines, thus restricting food intake and food absorption.

Before and 6 months after the surgery, the researchers evaluated patients' blood samples for natural killer (NK) cells, which play a critical role in controlling infections and cancer. Specifically, they measured the number of NK cells and the cells' capacity to kill infected cells or tumor cells. They also looked at the production of certain cytokines, proteins that are essential to the immune response.

Although the number of NK cells did not increase with surgically induced weight loss, their activity changed, Halpern said. Before surgery, NK cells mounted a weak immune defense, but after surgery their activity increased by nearly 79 percent, representing an improvement in the effective immune response and, possibly, in the ability to fight cancer and infections.

The response of cytokines involved in NK cell activity also changed after weight loss, possibly affording higher protection against infection and cancer, the researchers found. Cytokines analyzed were interferon-gamma and interleukins 2, 12 and 18.

Prior studies have shown that bariatric surgery has many health benefits, including resolution of type 2 diabetes, improved blood pressure and lower risk of premature death. This study shows another possible benefit of the weight loss stemming from bariatric surgery.

"It may help protect against infections and cancer by improving the activity of certain immune cells," Halpern said.

He said the impaired NK cell function evident in extremely obese people may even explain their propensity to develop infections and cancer.

Source: The Endocrine Society

Explore further: Pepper and halt: Spicy chemical may inhibit gut tumors

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Pepper and halt: Spicy chemical may inhibit gut tumors

12 hours ago

Researchers at the University of California, San Diego School of Medicine report that dietary capsaicin – the active ingredient in chili peppers – produces chronic activation of a receptor on cells lining ...

Expressive writing may help breast cancer survivors

13 hours ago

Writing down fears, emotions and the benefits of a cancer diagnosis may improve health outcomes for Asian-American breast cancer survivors, according to a study conducted by a researcher at the University of Houston (UH).

Taking the guesswork out of cancer therapy

19 hours ago

Researchers and doctors at the Institute of Bioengineering and Nanotechnology (IBN), Singapore General Hospital (SGH) and National Cancer Centre Singapore (NCCS) have co-developed the first molecular test ...

Brain tumour cells found circulating in blood

20 hours ago

(Medical Xpress)—German scientists have discovered rogue brain tumour cells in patient blood samples, challenging the idea that this type of cancer doesn't generally spread beyond the brain.

International charge on new radiation treatment for cancer

21 hours ago

(Medical Xpress)—Imagine a targeted radiation therapy for cancer that could pinpoint and blast away tumors more effectively than traditional methods, with fewer side effects and less damage to surrounding tissues and organs.

User comments : 1

Adjust slider to filter visible comments by rank

Display comments: newest first

E_L_Earnhardt
not rated yet Jun 17, 2008
Of Course! Accelerated mitosis, (cancer), is a direct result of excess energy in the form of high-spin electrons. Lower energy supply from intestines and you lower incidence of cancer! (Also may restrict angio genesis as a cause!)