Women, Mexican-Americans at higher risk of ruptured brain aneurysm

Jun 11, 2008

A type of stroke that can strike at any age, and kills one-third of its victims, appears to be more common in women and Mexican-Americans than in non-Hispanic white men, according to a new study from the University of Michigan Stroke Program.

In a paper published online June 11 by the journal Neurology, the researchers report that women had a 74 percent greater chance of suffering a type of stroke related to a ruptured brain aneurysm. Mexican-Americans of both genders had a 67 percent greater chance.

The type of stroke measured in the study is called a subarachnoid hemorrhage, or SAH. The new research may help public health officials reach out to higher-risk groups with information on prevention and the importance of rapid treatment.

The new paper also gives a "real world" picture of the risk of dying from an SAH, which was nearly one in three in the geographic region in the study. That region, Nueces County, Texas, where the city of Corpus Christi is located, has a large Mexican-American population and does not have a major university health system.

Although African Americans and Asian Americans were included in the initial screening portion of the study, which reviewed the medical records of 6,550 stroke patients, their numbers were too small to assess any differences in risk of SAH.

"Physicians and public health officials should help Mexican Americans and women take steps that might prevent subarachnoid hemorrhage, and other types of stroke that have already been shown to be more common in these two groups," says senior author Lewis Morgenstern, M.D. "Given that Mexican Americans are the largest and fastest-growing minority group in the United States, it's important to understand how this condition might affect them differently, and tailor messages to them."

Morgenstern, who directs the Stroke Program at the U-M Cardiovascular Center, is a professor of neurology and neurosurgery at the U-M Medical School, and of epidemiology at the U-M School of Public Health. The first author on the study, Sonia Eden, M.D., is a former chief resident in neurosurgery at U-M.

The study is the latest to arise from the BASIC project, whose name comes from Brain Attack Surveillance in Corpus Christi. The project involves surveillance for all strokes and mini-strokes in Nueces County, and detailed analysis of anonymous patient records.

Previously, using data from BASIC, Morgenstern and his colleagues have shown differences between ethnic groups and genders in other types of stroke – including the most common type, ischemic.

The new paper is based on data from 107 subarachoid hemorrhage patients over the age of 44 who experienced their stroke between 2000 and 2006. All of their diagnoses were validated by neurologists who reviewed their records in detail.

The reasons for the ethnic and gender differences seen in the new study are unclear, because the researchers were able to account and adjust for blood pressure, age, excessive alcohol use, smoking and health insurance status.

In all, 40 percent of the 107 SAH cases were in non-Hispanic whites, although 52 percent of the over-45 population in the study area is non-Hispanic white. Meanwhile, 60 percent of the SAH cases occurred in Mexican Americans, who make up 48 percent of the population over age 45 in the study area.

At the same time, 67.3 percent of SAH patients were women, though 53.5 percent of the population in the area is female. The researchers found that Mexican American women had the highest risk.

Subarachoid hemorrhages account for 3 percent of the 780,000 strokes that occur in the United States each year. Because these strokes arise from ruptured aneurysms, which are weak bulging spots in the brain's blood vessels that arise for unknown reasons at any stage of life, subarachnoid hemorrhages can occur at any time of life.

An SAH is different from the other type of "bleeding stroke," intracerebral hemorrhage or ICH, which can also result from a ruptured aneurysm or a misformed blood vessel called an arteriovenous malformation.

Both types of bleeding stroke are somewhat more dangerous than ischemic or "blockage" strokes, which result from a clot or other blockage inside a brain blood vessel. Ischemic strokes account for more than 85 percent of U.S. strokes.

The signs of an SAH usually include a sudden, extremely severe headache, often compared to a "thunderclap" inside the head. Patients may also experience neck pain, nausea and vomiting, or may lose consciousness.

No matter what the signs, a stroke or suspected stroke of any kind is a life-threatening emergency and needs immediate medical attention, says Morgenstern. Although SAH carries daunting odds, it can be treated if a patient reaches a hospital where a neurosurgeon or interventional radiologist can close off the ruptured aneurysm and stop the bleeding.

Source: University of Michigan

Explore further: Experts call for higher exam pass marks to close performance gap between international and UK medical graduates

add to favorites email to friend print save as pdf

Related Stories

Health care site flagged in Heartbleed review

3 hours ago

People with accounts on the enrollment website for President Barack Obama's signature health care law are being told to change their passwords following an administration-wide review of the government's vulnerability to the ...

Airbnb rental site raises $450 mn

3 hours ago

Online lodging listings website Airbnb inked a $450 million funding deal with investors led by TPG, a source close to the matter said Friday.

Four questions about missing Malaysian plane answered

3 hours ago

Travelers at Asian airports have asked questions about the March 8 disappearance of Malaysia Airlines Flight 370 while en route from Kuala Lumpur to Beijing. Here are some of them, followed by answers.

Recommended for you

Obese British man in court fight for surgery

Jul 11, 2011

A British man weighing 22 stone (139 kilograms, 306 pounds) launched a court appeal Monday against a decision to refuse him state-funded obesity surgery because he is not fat enough.

2008 crisis spurred rise in suicides in Europe

Jul 08, 2011

The financial crisis that began to hit Europe in mid-2008 reversed a steady, years-long fall in suicides among people of working age, according to a letter published on Friday by The Lancet.

New food labels dished up to keep Europe healthy

Jul 06, 2011

A groundbreaking deal on compulsory new food labels Wednesday is set to give Europeans clear information on the nutritional and energy content of products, as well as country of origin.

Overweight men have poorer sperm count

Jul 04, 2011

Overweight or obese men, like their female counterparts, have a lower chance of becoming a parent, according to a comparison of sperm quality presented at a European fertility meeting Monday.

User comments : 0

More news stories

Cancer stem cells linked to drug resistance

Most drugs used to treat lung, breast and pancreatic cancers also promote drug-resistance and ultimately spur tumor growth. Researchers at the University of California, San Diego School of Medicine have discovered ...

Making graphene in your kitchen

Graphene has been touted as a wonder material—the world's thinnest substance, but super-strong. Now scientists say it is so easy to make you could produce some in your kitchen.