Tamoxifen might be effective in the treatment of Leishmania amazonensis infections

Jun 11, 2008

Researchers from the University of São Paulo, Brazil, have shown the efficacy of an alternative drug against Leishmania amazonensis, one of the species that causes cutaneous leishmaniasis in South America. Details, published June 11th in the open-access journal PLoS Neglected Tropical Diseases, explain how tamoxifen – a medication widely used in the treatment and prevention of breast cancer – fights the parasitic disease in experimentally infected mice.

Unicellular parasites of Leishmania genus are the causative agents of leishmaniasis. Treatment of leishmaniasis requires the administration of toxic and poorly tolerated drugs. Having previously demonstrated that tamoxifen was active against parasites in vitro, the authors now show its efficacy in a rodent model of infection with L. amazonensis.

The Brazilian group, led by Silvia Uliana, observed that infected mice treated with 20 mg/kg/day of tamoxifen for 2 weeks showed a significant reduction in parasite burden. Researchers also detected a notable delay in the development of skin ulcers, a typical symptom of the disease caused by L. amazonensis.

The promising results presented in this study, coupled with the fact that tamoxifen's safety and pharmacological profiles in humans are well established, point to a new alternative in the treatment of leishmaniasis. Further trials will be necessary in other experimental models of infection before the drug is tested in humans.

Reference: www.plosntds.org/doi/pntd.0000249

Source: Public Library of Science

Explore further: Recorded Ebola deaths top 7,000

add to favorites email to friend print save as pdf

Related Stories

Why the Sony hack isn't big news in Japan

7 hours ago

Japan's biggest newspaper, Yomiuri Shimbun, featured a story about Sony Corp. on its website Friday. It wasn't about hacking. It was about the company's struggling tablet business.

Hopes, fears, doubts surround Cuba's oil future

8 hours ago

One of the most prolific oil and gas basins on the planet sits just off Cuba's northwest coast, and the thaw in relations with the United States is giving rise to hopes that Cuba can now get in on the action.

Ancient clay seals may shed light on biblical era

8 hours ago

Impressions from ancient clay seals found at a small site in Israel east of Gaza are signs of government in an area thought to be entirely rural during the 10th century B.C., says Mississippi State University archaeologist ...

Off-world manufacturing is a go with space printer

11 hours ago

On Friday, the BBC reported on a NASA email exchange with a space station which involved astronauts on the International Space Station using their 3-D printer to make a wrench from instructions sent up in ...

Recommended for you

Recorded Ebola deaths top 7,000

8 hours ago

The worst Ebola outbreak on record has now killed more than 7,000 people, with many of the latest deaths reported in Sierra Leone, the World Health Organization said as United Nations Secretary-General Ban ...

Liberia holds Senate vote amid Ebola fears (Update)

13 hours ago

Health workers manned polling stations across Liberia on Saturday as voters cast their ballots in a twice-delayed Senate election that has been criticized for its potential to spread the deadly Ebola disease.

Evidence-based recs issued for systemic care in psoriasis

Dec 19, 2014

(HealthDay)—For appropriately selected patients with psoriasis, combining biologics with other systemic treatments, including phototherapy, oral medications, or other biologic, may result in greater efficacy ...

Bacteria in caramel apples kills at least four in US

Dec 19, 2014

A listeria outbreak believed to originate from commercially packaged caramel apples has killed at least four people in the United States and sickened 28 people since November, officials said Friday.

Steroid-based treatment may answer needs of pediatric EoE patients

Dec 19, 2014

A new formulation of oral budesonide suspension, a steroid-based treatment, is safe and effective in treating pediatric patients with eosinophilic esophagitis (EoE), according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.