Brain cells help neighboring nerves regenerate

May 27, 2008

Researchers have uncovered a completely unexpected way that the brain repairs nerve damage, wherein cells known as astrocytes deliver a protective protein to nearby neurons.

Astrocytes are a type of support cell in the brain that serve many functions; one of their roles is to chew up damaged nerves during brain injury and then form scar tissue in the damaged area.

Roger Chung and colleagues have now found that astrocytes have another trick up their sleeve. During injury, astrocytes overproduce a protein called metallothionein (MT) and secrete it to surrounding nerves; MT is a scavenging protein that grabs free radicals and metal ions and prevents them from damaging a cell, and thus is a potent protecting agent.

While the ability of astrocytes to produce MT has been known for decades, the general view was that the MT stayed within astrocytes to protect them while they help repair damaged areas. However, Chung and colleagues demonstrated that MT was present in the external fluid of damaged rat brain. Furthermore, with the aid of a fluorescent MT protein, they observed that MT made in astrocytes could be transported outside the cell and then subsequently taken up by nearby nerves, and that the level of MT uptake correlated with how well the nerves repaired damage.

While the exact physiological role that MT plays in promoting better repair remains to be identified, this unexpected role for this protein should open up new avenues in treating brain injuries in the future.

Article URL: www.jbc.org/cgi/content/full/283/22/15349
The article is appearing in the May 30 Journal of Biological Chemistry.

Source: American Society for Biochemistry and Molecular Biology

Explore further: Team identifies possible bacterial drivers of inflammatory bowel diseases

add to favorites email to friend print save as pdf

Related Stories

Avatars make the Internet sign to deaf people

25 minutes ago

It is challenging for deaf people to learn a sound-based language, since they are physically not able to hear those sounds. Hence, most of them struggle with written language as well as with text reading ...

What time is it in the universe?

5 minutes ago

Flavor Flav knows what time it is. At least he does for Flavor Flav. Even with all his moving and accelerating, with the planet, the solar system, getting on planes, taking elevators, and perhaps even some ...

Recommended for you

User comments : 0