Research shows HPV testing offers women protection for twice as long as smear testing

May 15, 2008

The long term findings of a study carried out at Hammersmith hospital reveal that testing for Human Papilloma Virus (HPV) can be twice as effective at protecting women from developing cervical abnormalities as smear testing. Results of the research – led by Professor Jack Cuzick of Barts and The London School of Medicine and Dentistry - are published today in the International Journal of Cancer.

Nearly 3,000 women aged 35+ were recruited into the study between April 1994 and September 1997. They were asked to participate in a study in which HPV testing would be performed in addition to cytology (smear test) whilst attending their GP practice (40 practices were involved in the trial) for a routine cervical smear.

Women who had previously been treated for cervical intra-epithelial neoplasia (CIN) – changes to cells in the cervix that can develop into cancer – or had experienced any cervical abnormality within the previous 3 years, were excluded from the study.

All women tested were followed up passively using data from the national computerised system that records all smears and their results – the Open-Exeter system. Women with a smear history indicating the need for colposcopy – a more thorough examination of the cervix – were investigated further to determine whether the colposcopy and biopsy were performed, and what the resultant outcome was. Passive follow-up was complete for all women by early 2005.

Results showed that the risk of developing cervical abnormalities at 1, 5, and 9 years after a normal smear test was 0.33 per cent, 0.83 per cent, and 2.20 per cent respectively, with those odds significantly reduced after a negative HPV test - 0.19 per cent, 0.42 per cent, and 1.88 per cent.

Professor Jack Cuzick said: “Not only does the research confirm that HPV testing detects more disease at each smear, it shows that this approach offers women excellent protection from cervical abnormalities for at least 6 years after a negative test, compared to protection from a normal smear test which begins to wane after about 3 years.

This suggests that the screening interval can be safely extended to at least 6 years with HPV testing. These data provide more support for replacing screening based on abnormal cells, with a more sensitive test based on screening for the human papillomavirus.”

Source: Queen Mary, University of London

Explore further: Study identifies enzymes that help fix cancer-causing DNA defects

add to favorites email to friend print save as pdf

Related Stories

Study urges three-year gap in cervical cancer test

May 18, 2011

Healthy women over 30 who test negative for human papillomaviruses (HPV) may be able to safely extend the period between gynecological exams from every year to three years, said a US study Wednesday.

Should cervical screening stop at age 50?

Apr 24, 2009

It is not consistent to stop screening women after age 50 because the risk of cervical cancer - even after several negative smear results - is similar to that at younger ages, concludes a study published on bmj.com today.

HPV test beats Pap for cervical cancer screening

May 18, 2011

Two big studies suggest possible new ways to screen healthy people for cervical or prostate cancers, but a third disappointed those hoping for a way to detect early signs of deadly ovarian tumors.

US approves Swiss firm's cervical cancer test

Apr 20, 2011

Swiss pharmaceutical giant Roche has been given the green light by US authorities to market its test for screening cervical cancer, the company announced on Wednesday.

Recommended for you

Cancer patients need anxiety, depression screening

12 hours ago

(HealthDay)—It is important to recognize and treat anxiety or depression among cancer patients, according to a clinical guideline published online April 14 in the Journal of Clinical Oncology.

Pre-HPV vaccine, most oropharyngeal cancers HPV+

13 hours ago

(HealthDay)—Most oropharyngeal cancers in the United States diagnosed between 1995 and 2005 were positive for human papillomavirus (HPV), specifically HPV 16 or 18, according to a study published in the May issue of the ...

User comments : 0

More news stories

Computer screening could help patients and healthcare

A trial of a new patient care model, which uses over-the-phone consultations and computers to help better understand the needs of the patient, has begun this week, led by researchers at the University of Adelaide.

In the 'slime jungle' height matters

(Phys.org) —In communities of microbes, akin to 'slime jungles', cells evolve not just to grow faster than their rivals but also to push themselves to the surface of colonies where they gain the best access ...

Robot scouts rooms people can't enter

(Phys.org) —Firefighters, police officers and military personnel are often required to enter rooms with little information about what dangers might lie behind the door. A group of engineering students at ...

New alfalfa variety resists ravenous local pest

(Phys.org) —Cornell plant breeders have released a new alfalfa variety with some resistance against the alfalfa snout beetle, which has ravaged alfalfa fields in nine northern New York counties and across ...