Assembling the jigsaw puzzle of drug addiction

Jan 05, 2008

Using an integrative meta-analysis approach, researchers from the Center for Bioinformatics at Peking University in Beijing have assembled the most comprehensive gene atlas underlying drug addiction and identified five molecular pathways common to four different addictive drugs. This novel paper appears in PLoS Computational Biology on January 4, 2008.

Drug addiction is a serious worldwide problem with strong genetic and environmental influences. So far different technologies have revealed a variety of genes and biological processes underlying addiction. However, individual technology can be biased and render only an incomplete picture. Studying individual or a small number of genes is like looking at pieces of a jigsaw puzzle - only when you gather most of the pieces from different places and arrange them together in an orderly fashion do interesting patterns emerge.

The team, led by Liping Wei, surveyed scientific literature published in the past 30 years and collected 2,343 items of evidence linking genes and chromosome regions to addiction based on single-gene strategies, microarray, proteomics, or genetic studies. They made this gene atlas freely available in the first online molecular database for addiction, named KARG (karg.cbi.pku.edu.cn), with extensive annotations and friendly web interface.

Assembling the pieces of evidence together, the authors identified 18 molecular pathways that are statistically enriched in the addiction-related genes. They then identified five pathways that are common to addiction to four different substances. These common pathways may underlie shared rewarding and response mechanisms and may be targets for effective treatments for a wide range of addictive disorders.


Source: Public Library of Science

Explore further: Novel gene variants found in a difficult childhood immune disorder

add to favorites email to friend print save as pdf

Related Stories

'Bright spot' on Ceres has dimmer companion

1 hour ago

Dwarf planet Ceres continues to puzzle scientists as NASA's Dawn spacecraft gets closer to being captured into orbit around the object. The latest images from Dawn, taken nearly 29,000 miles (46,000 kilometers) ...

Key facts on US 'open Internet' regulation

1 hour ago

A landmark ruling by the US Federal Communications Commission seeks to enshrine the notion of an "open Internet," or "net neutrality." Here are key points:

Spotify deals with random shuffle and we mortals

1 hour ago

How do we mortals perceive random sequences? An entry in the question-and-answer site Quora focused on a question involving a music-streaming service Spotify. That question signifies how we perceive what ...

Top-precision optical atomic clock starts ticking

1 hour ago

A state-of-the-art optical atomic clock, collaboratively developed by scientists from the University of Warsaw, Jagiellonian University, and Nicolaus Copernicus University, is now "ticking away" at the National ...

Recommended for you

Exploring the genetic origins of autism

Feb 25, 2015

The geneticist S├ębastien Jacquemont is the new holder of the Canada Research Chair in Genetics of Neurodevelopmental Disorders and Associated Dysregulation in Energy Balance at the University of Montreal. He moved to the ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.