A low-carb diet may stunt prostate tumor growth

Nov 13, 2007

A diet low in carbohydrates may help stunt the growth of prostate tumors, according to a new study led by Duke Prostate Center researchers. The study, in mice, suggests that a reduction in insulin production possibly caused by fewer carbohydrates may stall tumor growth.

“This study showed that cutting carbohydrates may slow tumor growth, at least in mice,” said Stephen Freedland, M.D., a urologist at Duke University Medical Center and lead researcher on the study. “If this is ultimately confirmed in human clinical trials, it has huge implications for prostate cancer therapy through something that all of us can control, our diets.”

Freedland conducted most of the research for this study while doing a fellowship in urology at Johns Hopkins’ Brady Urological Institute under the tutelage of William Isaacs, Ph.D., a molecular geneticist there.

The researchers published their results on November 13, 2007 in the online edition of the journal Prostate. The study was funded by the Department of Veterans Affairs, the Department of Surgery and the Division of Urology at Duke University Medical Center, the Prostate Cancer Foundation, and the Department of Defense Prostate Cancer Research Program.

The researchers hypothesized that since serum insulin and a related substance known as insulin-like growth factor (IGF) had been linked with the growth of prostate tumors in earlier research in mice, a reduction in the body’s levels of these substances might slow tumor growth, Freedland said.

The researchers compared tumor growth in 75 mice that were eating either a low-carbohydrate diet, a low-fat but high-carbohydrate diet, or a Western diet, high in fat and carbohydrates.

The mice that ate a low-carbohydrate diet had the longest survival and smallest tumor size, Freedland said.

“Low-fat mice had shorter survival and larger tumors while mice on the Western diet had the worst survival and biggest tumors,” he said. “In addition, though both the low-carb and low-fat mice had lower levels of insulin, only the low-carb mice had lower levels of the form of IGF capable of stimulating tumor growth.”

The low-carbohydrate diet definitely had the most significant effect on tumor growth and survival, he said.

The next step will be to test the findings of this study in humans, and further examine the potential positive effects that a low-carbohydrate diet may have on tumor growth, Freedland said.

“We are planning to start clinical trials sometime next year,” he said. “The results of this study are very promising, but of course much more work needs to be done.”

Source: Duke University Medical Center

Explore further: Survival differences seen for advanced-stage laryngeal cancer

add to favorites email to friend print save as pdf

Related Stories

3-D images show flame retardants can mimic estrogens

Aug 19, 2013

By determining the three-dimensional structure of proteins at the atomic level, researchers at the National Institutes of Health have discovered how some commonly used flame retardants, called brominated ...

3Qs: Considering new data on genetically modified corn

Oct 03, 2012

An article recently pub­lished in the journal Food and Chem­ical Tox­i­cology shows the results of a two-​​year study on the health effects of a corn species pro­duced by the agri­cul­tural giant ...

Bile acids link high-fat diet to colon cancer

Feb 09, 2011

(PhysOrg.com) -- Bile acids could be the missing link between a high-fat, Western-style diet and colon cancer, UA researchers Carol and Harris Bernstein and their collaborators have discovered.

Recommended for you

Gene test aids cancer profile

16 hours ago

The first round of chemotherapy did little to suppress Ron Bose's leukemia. The second round, with 10 times the dose, knocked the proliferating blast cells down, but only by half.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.