Chronic kidney disease rises while most people with the condition remain unaware

Nov 09, 2007

A growing number of Americans have chronic kidney disease, but most remain unaware of it, hampering efforts to prevent irreversible kidney failure requiring dialysis or a transplant, according to a study funded by the National Institutes of Health and published November 7 in the Journal of the American Medical Association.

An estimated 26 million people — about 13 percent of the U.S. population — now have chronic kidney disease, say researchers at Johns Hopkins University in Baltimore, Tufts-New England Medical Center in Boston and Cleveland Clinic Foundation. This new report raises by 3 percent the previous estimate of 20 million people with the disease in 1994.

“Increases in diabetes, hypertension, obesity, and the aging U.S. population explain at least some of the increase,” says co-author Paul W. Eggers, Ph.D., director of kidney disease epidemiology at the National Institute of Diabetes and Digestive and Kidney Diseases, part of the NIH. “We don’t know what may be responsible for the rest.”

The study analyzed and compared National Health and Nutrition Examination Survey data on adults age 20 or older from 1988 to 1994 and 1999 to 2004. More than 15,000 and 13,000 adults, respectively, were interviewed at home and had a physical exam and blood and urine tests. The surveys were conducted by the National Center for Health Statistics, part of the Centers for Disease Control and Prevention.

Kidney function was estimated for each participant with a formula that considers the amount of creatinine in a blood sample, along with age, gender and African American race, which can affect results. Creatinine is a waste product created by normal breakdown of muscle cells during activity. When kidneys are ailing, creatinine builds up in the blood. A small sample of urine was checked for a protein called albumin. Damaged kidneys may persistently leak albumin from the blood into the urine, sometimes even when kidney function appears normal.

Awareness of chronic kidney disease is up, but most people who have the condition still don’t know it. Between 1999 and 2004, survey participants were asked if they had been told they had “weak or failing kidneys.” The authors report that only 11.6 percent of men and 5.5 percent of women with moderate (stage 3) kidney disease knew it. Awareness increased to 22.8 percent among participants with stage 3 disease and albumin in the urine. Awareness was highest among people with severe (stage 4) kidney disease, only 42 percent of whom knew they had the condition. Stage 5 is kidney failure.

“Kidney disease is often silent until late stages, but if we can find it early we can do a lot to prevent kidney failure,” explained Andrew S. Narva, M.D., F.A.C.P., a kidney specialist at the NIH. “If you have diabetes, high blood pressure or a family history of kidney problems you are at risk and should be screened for kidney damage with routine blood and urine tests.”

“To help protect the kidneys’ small blood vessels, carefully control high blood pressure, and blood sugar if you’re diabetic, and ask your doctor if you should take an angiotensin converting enzyme inhibitor or angiotensin receptor blocker,” advised Narva, also director of the NIH’s National Kidney Disease Education Program.

Source: National Institute of Diabetes and Digestive and Kidney Diseases

Explore further: Ebola reveals shortcomings of African solidarity

add to favorites email to friend print save as pdf

Related Stories

Colorful nano-guides to the liver

Dec 03, 2014

Jena scientists have been successful in producing highly specific nanoparticles. Depending on the bound dye the particles are guided to the liver or to the kidney and deliver their payload of active ingredients ...

Recommended for you

Ebola-hit Liberia delays school reopening

1 hour ago

Liberia's education ministry said on Sunday it had postponed by two weeks the reopening of the country's schools, which were closed six months ago to limit the spread of the Ebola virus.

Ebola: timeline of a ruthless killer

10 hours ago

Here are key dates in the current Ebola epidemic, the worst ever outbreak of the haemorrhagic fever which first surfaced in 1976 in the Democratic Republic of Congo (DRC).

Ebola reveals shortcomings of African solidarity

Jan 31, 2015

As Africa's leaders meet in Ethiopia to discuss the Ebola crisis, expectations of firm action will be tempered by criticism over the continent's poor record in the early stages of the epidemic.

Second bird flu case confirmed in Canada

Jan 30, 2015

The husband of a Canadian who was diagnosed earlier this week with bird flu after returning from a trip to China has also tested positive for the virus, health officials said Friday.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.