In the laboratory, green tea proves a powerful medicine against severe sepsis

Nov 08, 2007

A major component of green tea could prove the perfect elixir for severe sepsis, an abnormal immune system response to a bacterial infection.

In a new laboratory study, Haichao Wang, PhD, of The Feinstein Institute for Medical Research, and his colleagues have been studying the therapeutic powers of dozens of Chinese herbal compounds in reversing a fatal immune response that kills 225,000 Americans every year. They found that an ingredient in green tea rescued mice from lethal sepsis – and the findings could pave the way to clinical trials in patients.

The study was published this week in the Public Library of Science, or PLoS-ONE. Dr. Wang had previously discovered a late mediator of sepsis called HMGB1, a substance expressed in the late stages of lethal sepsis. They wanted to figure out a way to block this substance, which they felt would prevent the lethal sepsis process from moving forward. And it worked.

Scientists worldwide have been stumped by sepsis. Even with the most advanced medical techniques available, half of those who develop sepsis die of the massive assault on the body. Several laboratories at the Feinstein Institute are working on sepsis – both on the basic biological level and in patients.

In the latest study, Dr. Wang’s group gave a substance in green tea called EGCG to mice in the throes of severe sepsis. The dose was equivalent to 10 cups in a human. Survival jumped from 53 percent in those who didn’t receive the green tea substance to 82 percent in those who did. “Clinically, even if we could save five percent of patients, that would be huge,” said Dr. Wang. “In this study, we saved 25 percent more animals with the green tea.” He said that the green tea component, EGCG, is readily available.

There have been more than 100 papers focusing on this natural substance and its anti-cancer benefits. “This compound prevents HMGB1 from being released by immune cells and it also prevents it from activating immune cells to produce more cytokines,” he said. Cytokines are produced by immune cells and act as weapons to defend the body against invaders. “We are hoping to stimulate future interest in clinical studies,” said Dr. Wang, who worked on the study in collaboration with Wei Li, PhD, Andrew Sama, MD, chairman of emergency medicine at North Shore University Hospital, and other Feinstein investigators.

Source: North Shore-Long Island Jewish Health System

Explore further: Estimates show preterm birth complications and pneumonia are leading causes of death in children under five years

add to favorites email to friend print save as pdf

Related Stories

Hide and seek: Sterile neutrinos remain elusive

1 hour ago

The Daya Bay Collaboration, an international group of scientists studying the subtle transformations of subatomic particles called neutrinos, is publishing its first results on the search for a so-called ...

Cyanide ice in Titan's atmosphere

1 hour ago

Gigantic polar clouds of hydrogen cyanide roughly four times the area of the UK are part of the impressive atmospheric diversity of Titan, the largest moon of Saturn, a new study led by Leiden Observatory, ...

Genetic secrets of the monarch butterfly revealed

1 hour ago

The monarch butterfly is one of the most iconic insects in the world, best known for its distinct orange and black wings and a spectacular annual mass migration across North America. However, little has been ...

Recommended for you

More involvement needed in models of care

4 hours ago

Clinicians and health administrators need to take a more active role in implementing and evaluating models of care (MoCs) for musculosketal health, according to a recent study.

Researchers developing a digital maternity package

5 hours ago

Every Finnish expectant mother can choose to receive a free of charge maternity package containing baby clothes and other useful items. VTT Technical Research Centre of Finland is currently developing a digital maternity ...

User comments : 0