FDA approves antiretroviral drug

Aug 07, 2007

The U.S. Food and Drug Administration has approved the antiretroviral drug maraviroc for use in adult human immunodeficiency virus patients.

The FDA said maraviroc, sold under the trade name Selzentry, is the first in a new class of drugs designed to slow the advancement of HIV.

Maraviroc is approved for use in combination with other antiretroviral drugs for the treatment of adults with CCR5-tropic HIV-1, who have been treated with other HIV medications and who have evidence of elevated levels of HIV in their blood, the FDA said.

Rather than fighting HIV inside white blood cells, maraviroc prevents the virus from entering uninfected cells by blocking the predominant route of entry -- the CCR5 co-receptor. CCR5 is a protein on the surface of some types of immune cells.

"This is an important new product for many HIV-infected patients who have not responded to other treatments and have few options," said Dr. Steven Galson, director of the FDA's Center for Drug Evaluation and Research.

The product label includes a boxed warning about liver toxicity -- hepatoxicity -- and a statement about the possibility of heart attacks.

Maraviroc is distributed by Pfizer Inc.

Copyright 2007 by United Press International

Explore further: FDA: generic copaxone approved for multiple sclerosis

Related Stories

United States, China team explore energy harvesting

33 minutes ago

Six authors have described their work in harvesting energy in a paper titled "Ultrathin, Rollable, Paper-Based Triboelectric Nanogenerator for Acoustic Energy Harvesting and Self-Powered Sound Recording." ...

China's struggle for water security

2 hours ago

Way back in 1999, before he became China's prime minister, Wen Jiabao warned that water scarcity posed one of the greatest threats to the "survival of the nation".

Canada revises upward CO2 emission data since 1990

2 hours ago

Canada revised its greenhouse gas emission data from 1990 to 2013 in a report Friday, showing it had higher carbon dioxide discharges each year, and a doubling of emissions from its oil sands.

Recommended for you

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.