FDA approves antiretroviral drug

Aug 07, 2007

The U.S. Food and Drug Administration has approved the antiretroviral drug maraviroc for use in adult human immunodeficiency virus patients.

The FDA said maraviroc, sold under the trade name Selzentry, is the first in a new class of drugs designed to slow the advancement of HIV.

Maraviroc is approved for use in combination with other antiretroviral drugs for the treatment of adults with CCR5-tropic HIV-1, who have been treated with other HIV medications and who have evidence of elevated levels of HIV in their blood, the FDA said.

Rather than fighting HIV inside white blood cells, maraviroc prevents the virus from entering uninfected cells by blocking the predominant route of entry -- the CCR5 co-receptor. CCR5 is a protein on the surface of some types of immune cells.

"This is an important new product for many HIV-infected patients who have not responded to other treatments and have few options," said Dr. Steven Galson, director of the FDA's Center for Drug Evaluation and Research.

The product label includes a boxed warning about liver toxicity -- hepatoxicity -- and a statement about the possibility of heart attacks.

Maraviroc is distributed by Pfizer Inc.

Copyright 2007 by United Press International

Explore further: National Cancer Institute supports next-generation Austrian HPV vaccine

add to favorites email to friend print save as pdf

Related Stories

HIV drug maraviroc effective for drug-resistant patients

Oct 01, 2008

As many as one quarter of HIV patients have drug resistance, limiting their treatment options and raising their risk for AIDS and death. Now, maraviroc, the first of a new class of HIV drugs called CCR5 receptor antagonists, ...

Recommended for you

A new tool in drug overdose prevention

6 hours ago

The Center for Disease Control reported earlier this month that the heroin overdose death rate across 28 states it surveyed doubled between 2010 and 2012. This sharp increase and the chilling statistics that say more than 11 ...

Nasal spray treats heroin overdose

Oct 28, 2014

"Every year, drug overdoses are responsible for roughly 1000 ambulance calls in Oslo," says Arne Skulberg, an anaesthesiologist, a PhD candidate at NTNU and the 2014 winner of Norway's Researcher Grand Prix ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.