Patient dies during gene therapy trial

Jul 27, 2007

U.S. health officials say a patient died while participating in a gene therapy experiment to treat arthritis.

The precise cause of death is unknown, The Washington Post said Friday.

The Food and Drug Administration said it was informed by Targeted Genetics Corp. of Seattle the patient died while receiving an investigational gene therapy product in a clinical trial for the treatment of active inflammatory arthritis, the agency said in a release.

The FDA said it has placed the trial on clinical hold, which means no further product can be administered and no new patients can be enrolled.

The product being studied used a recombinant adeno-associated virus (AAV) derived vector. It was administered into the arthritic joint to reduce inflammation.

The company said more than 100 subjects have been enrolled in the trial, with no other known adverse effects. As a precaution, however, the FDA said it is further reviewing all ongoing trials involving any use of AAV.

Copyright 2007 by United Press International

Explore further: Kidney transplant drug halves the early risk of rejection and allows less toxic treatment

add to favorites email to friend print save as pdf

Related Stories

Hoverbike drone project for air transport takes off

4 hours ago

What happens when you cross a helicopter with a motorbike? The crew at Malloy Aeronautics has been focused on a viable answer and has launched a crowdfunding campaign to support its Hoverbike project, "The ...

Study indicates large raptors in Africa used for bushmeat

4 hours ago

Bushmeat, the use of native animal species for food or commercial food sale, has been heavily documented to be a significant factor in the decline of many species of primates and other mammals. However, a new study indicates ...

'Shocking' underground water loss in US drought

5 hours ago

A major drought across the western United States has sapped underground water resources, posing a greater threat to the water supply than previously understood, scientists said Thursday.

Recommended for you

Burnout impacts transplant surgeons (w/ Video)

6 hours ago

Despite saving thousands of lives yearly, nearly half of organ transplant surgeons report a low sense of personal accomplishment and 40% feel emotionally exhausted, according to a new national study on transplant surgeon ...

User comments : 0