Patient dies during gene therapy trial

Jul 27, 2007

U.S. health officials say a patient died while participating in a gene therapy experiment to treat arthritis.

The precise cause of death is unknown, The Washington Post said Friday.

The Food and Drug Administration said it was informed by Targeted Genetics Corp. of Seattle the patient died while receiving an investigational gene therapy product in a clinical trial for the treatment of active inflammatory arthritis, the agency said in a release.

The FDA said it has placed the trial on clinical hold, which means no further product can be administered and no new patients can be enrolled.

The product being studied used a recombinant adeno-associated virus (AAV) derived vector. It was administered into the arthritic joint to reduce inflammation.

The company said more than 100 subjects have been enrolled in the trial, with no other known adverse effects. As a precaution, however, the FDA said it is further reviewing all ongoing trials involving any use of AAV.

Copyright 2007 by United Press International

Explore further: AbbVie shares sink after $21 bn deal for Pharmacyclics

add to favorites email to friend print save as pdf

Related Stories

Synthetic biology yields new approach to gene therapy

Feb 16, 2015

Bioengineers at The University of Texas at Dallas have created a novel gene-delivery system that shuttles a gene into a cell, but only for a temporary stay, providing a potential new gene-therapy strategy ...

Scientists help avert a nuclear medicine meltdown

Jan 09, 2015

University of British Columbia scientists have shown that small cyclotrons – particle accelerators the size of an SUV – can replace hulking nuclear power plants as the country's main source of medical ...

Using 3D printers to print out self-learning robots

Nov 12, 2014

When the robots of the future are set to extract minerals from other planets, they need to be both self-learning and self-repairing. Researchers at Oslo University have already succeeded in producing self-instructing ...

What exactly is Google's 'cancer nanodetector'?

Nov 11, 2014

Last week, US tech giants Google made a splash in the media, announcing plans to develop new 'disease-detecting magnetic nanoparticles'. This was almost universally welcomed – after all, trying to detect ...

Recommended for you

US must respond to global health outbreaks, say bioethicists

Mar 05, 2015

Last summer, West Africa fell into the grip of a deadly outbreak of Ebola that has thus far taken the lives of more than 9,500 people. The fear swept up by the epidemic quickly jumped across the Atlantic and landed in the ...

Uganda on defensive over medical 'brain drain' uproar

Mar 03, 2015

Uganda's government on Tuesday hit back at mounting criticism of plans to 'export' over 200 health workers to the Caribbean, insisting it was only seeking to regulate an existing labour market and prevent abuses.

Seth Mnookin on vaccination and public health

Mar 02, 2015

Seth Mnookin, an assistant professor of science writing and associate director of MIT's Graduate Program in Science Writing, is the author of "The Panic Virus: The True Story Behind the Vaccine-Autism Controversy" ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.