Patient dies during gene therapy trial

Jul 27, 2007

U.S. health officials say a patient died while participating in a gene therapy experiment to treat arthritis.

The precise cause of death is unknown, The Washington Post said Friday.

The Food and Drug Administration said it was informed by Targeted Genetics Corp. of Seattle the patient died while receiving an investigational gene therapy product in a clinical trial for the treatment of active inflammatory arthritis, the agency said in a release.

The FDA said it has placed the trial on clinical hold, which means no further product can be administered and no new patients can be enrolled.

The product being studied used a recombinant adeno-associated virus (AAV) derived vector. It was administered into the arthritic joint to reduce inflammation.

The company said more than 100 subjects have been enrolled in the trial, with no other known adverse effects. As a precaution, however, the FDA said it is further reviewing all ongoing trials involving any use of AAV.

Copyright 2007 by United Press International

Explore further: Is head CT overused in emergency departments?

add to favorites email to friend print save as pdf

Related Stories

Black hole chokes on a swallowed star

44 minutes ago

A five-year analysis of an event captured by a tiny telescope at McDonald Observatory and followed up by telescopes on the ground and in space has led astronomers to believe they witnessed a giant black hole ...

Montana oil spill estimate lowered to 30,000 gallons

1 hour ago

Authorities have lowered their estimate of how much oil spilled from a broken pipeline beneath the Yellowstone River in eastern Montana, briefly contaminating the water supply of a city downstream.

Researchers use oxides to flip graphene conductivity

1 hour ago

Graphene, a one-atom thick lattice of carbon atoms, is often touted as a revolutionary material that will take the place of silicon at the heart of electronics. The unmatched speed at which it can move electrons, ...

Recommended for you

Is head CT overused in emergency departments?

6 hours ago

Less than 7.1% of patients presenting to the emergency department with dizziness and 6.4% complaining of syncope or near-syncope benefited from head CT say researchers at Kaiser Foundation Hospital in Honolulu. The use of ...

Medical radiation may be reduced to one-sixth

8 hours ago

One of this century's most significant mathematical discoveries may reduce the number of measuring points to one-sixth of the present level. This means reduced exposure to radiation and faster medical imaging ...

The 'fifth taste,' umami, could be beneficial for health

21 hours ago

The umami taste could have an important and beneficial role in health, according to research published in the open access journal Flavour. The journal's special series of articles 'The Science of Taste' also finds that ' ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.