Men and women equally transmit genetic risk of MS to their children

Jun 27, 2007

Men and women with multiple sclerosis (MS) equally transmit the genetic risk of the disease to their children, according to a study published June 27, 2007, in the online edition of Neurology, the medical journal of the American Academy of Neurology. The research contradicts the results of a recent study, which found affected fathers were more likely than affected mothers to transmit the risk of developing MS to their children.

Researchers studied 3,088 Canadian families with one parent affected with MS. Of the 8,401 children in those families, 798 had MS.

The study found equal transmission of the genetic risk of MS to children with 9.41 percent of fathers transmitting MS to their children compared to 9.76 percent of mothers.

“We also found there were equal numbers of daughters and sons receiving the genetic risk of the disease from their parents,” said study author George Ebers, MD, FMedSci, Action Research Professor of Clinical Neurology at the University of Oxford. “Intriguingly, we also found when half siblings both have MS, there is a clear maternal effect with mothers much more likely to be the common parent.”

Ebers says the findings show no evidence of the Carter effect, which was recently cited in a study that found men with MS were twice as likely to pass the risk of disease on to their children. According to the Carter effect, men are more resistant to MS because they carry a higher genetic load and thus are more likely to transmit the genetic risk of the disease to their children.

“Our study involved 16 times as many people as the previous published study. It casts further doubt on the widely believed multiple gene mode of inheritance of susceptibility to MS,” said Ebers.

Source: American Academy of Neurology

Explore further: Investigators show how immune cells are 'educated' not to attack beneficial bacteria

Related Stories

Cheap content, growing reach make Snapchat a fast-rising star

5 hours ago

Thousands of revelers descended on the Coachella music festival this month to rock out to their favorite bands and party day and night. But a far bigger audience from around the world - at least 40 million - joined in remotely ...

Google prepares for long battle in EU antitrust case

6 hours ago

Google Inc. probably faces a lengthy process in challenging antitrust charges by the European Union, but the Internet search giant might be able to avoid paying hefty fines or making big changes to its business.

Comcast expands 2-gigabit Internet service

6 hours ago

–In the race for speed, Comcast soon will offer the fastest residential Internet speed in the country to its 1.3 million residential customers in South Florida.

Recommended for you

Fat signals control energy levels in the brain

Apr 23, 2015

An enzyme secreted by the body's fat tissue controls energy levels in the brain, according to new research at Washington University School of Medicine in St. Louis. The findings, in mice, underscore a role ...

Human tape worm drug shows promise against MRSA in lab

Apr 23, 2015

A new study provides evidence from lab experiments that a drug already used in people to fight tapeworms might also prove effective against strains of the superbug MRSA, which kills thousands of people a ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.