AIDS associated with an increased risk of some stomach, esophageal cancers

Apr 04, 2011

Among people with AIDS, the risk of stomach and esophageal malignancies is higher than among the general population, according to study results presented at the AACR 102nd Annual Meeting 2011, held here April 2-6.

"People diagnosed with AIDS are living longer due to improved therapies. However, they are at increased risk of developing a number of different cancers, including Kaposi's sarcoma and several lymphomas. The risk of stomach and esophageal cancers in AIDS patients has not previously been fully evaluated," said E. Christina Persson, Ph.D., a postdoctoral fellow at the National Cancer Institute.

Persson and colleagues utilized data from the HIV/AIDS Cancer Match Study, a linkage of 15 U.S. population-based HIV/AIDS and cancer registries with data from 1980 through 2007. The study included 600,000 men and women diagnosed with AIDS, of whom 1,166 developed stomach malignancies and 240 developed esophageal malignancies.

Overall, people with AIDS had a 6.9-fold increased incidence of stomach malignancies compared to the general population. The risk was increased 70 percent for stomach carcinomas, with similar increases for proximal (cardia) and distal (non-cardia) carcinomas. The risk for stomach lymphomas was 36-fold higher.

The overall risk of esophageal malignancies was 2.7 times higher among people with AIDS than in the general population. Risk was increased 54 percent for squamous cell carcinomas, 101 percent for adenocarcinomas, and 261-fold for lymphomas of the esophagus.

Persson said that the increased risk among patients with AIDS was expected, but the increased risk for carcinomas is a new finding. Additionally, the size of this study allowed the researchers to look at subtypes.

"This study is unique because of its large size, which allowed us to look more closely at the different histologic and anatomic subsites of the tumors," said Persson. "It will be important for us to evaluate trends in risk over time, particularly in the modern treatment era."

Explore further: Pepper and halt: Spicy chemical may inhibit gut tumors

add to favorites email to friend print save as pdf

Related Stories

Individuals with HIV have higher risk of non-AIDS cancers

Nov 18, 2008

The risk of non-AIDS cancer is higher for individuals infected with HIV than for the general population, according to a meta-analysis presented here at the American Association for Cancer Research's Seventh Annual International ...

Cancer risk in HIV, transplant patients

Jul 06, 2007

HIV/AIDS and kidney transplant patients are at much greater risk of contracting 20 different types of cancer than the general population, according to a land mark paper in The Lancet.

H. Pylori bacteria may help prevent some esophageal cancers

Oct 06, 2008

Some bacteria may help protect against the development of a type of esophageal cancer, known as adenocarcinoma, according to a new review of the medical literature. These bacteria, which are called Helicobacter pylori, live i ...

More AIDS patients die of other causes

Sep 19, 2006

New York's Bureau of HIV/AIDS Prevention and Control report has said it is becoming less common for AIDS patients to die of causes related to the disease.

Recommended for you

Pepper and halt: Spicy chemical may inhibit gut tumors

7 hours ago

Researchers at the University of California, San Diego School of Medicine report that dietary capsaicin – the active ingredient in chili peppers – produces chronic activation of a receptor on cells lining ...

Expressive writing may help breast cancer survivors

9 hours ago

Writing down fears, emotions and the benefits of a cancer diagnosis may improve health outcomes for Asian-American breast cancer survivors, according to a study conducted by a researcher at the University of Houston (UH).

Taking the guesswork out of cancer therapy

14 hours ago

Researchers and doctors at the Institute of Bioengineering and Nanotechnology (IBN), Singapore General Hospital (SGH) and National Cancer Centre Singapore (NCCS) have co-developed the first molecular test ...

Brain tumour cells found circulating in blood

15 hours ago

(Medical Xpress)—German scientists have discovered rogue brain tumour cells in patient blood samples, challenging the idea that this type of cancer doesn't generally spread beyond the brain.

International charge on new radiation treatment for cancer

16 hours ago

(Medical Xpress)—Imagine a targeted radiation therapy for cancer that could pinpoint and blast away tumors more effectively than traditional methods, with fewer side effects and less damage to surrounding tissues and organs.

User comments : 0