The relationship between body mass index and age at hepatocellular carcinoma onset

Mar 15, 2011

A research team from Japan identified factors associated with the age at onset of hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC). The results showed that increased body mass index (BMI) is associated with increased risk for early HCC development in HCV-infected patients. Achieving recommended BMI and reducing alcohol intake could help prevent hepatic carcinogenesis.

The incidence and mortality associated with hepatocellular carcinoma (HCC) have been increasing worldwide, and virus (HCV) infection plays an important role in the pathogenesis of HCC. Previous studies have suggested that host factors, such as sex, , smoking, diabetes mellitus, and obesity, are important risk factors for HCC. Meanwhile, it has been reported that HCV infection causes and leads to oxidative stress, potentiating fibrosis and hepatic carcinogenesis. However, the factors that influence the development of HCC in HCV-infected patients remain largely unknown.

A research article published on February 21, 2011 in the addresses this question. The authors hypothesized that obesity influences the time to onset of HCC related to HCV infection, which is reflected in the patient's age at onset. To test this hypothesis, they investigated the relationship between (BMI) and lifestyle factors and age at onset of HCC in HCV-infected patients.

The research showed that the underweight patients (BMI < 18.5 kg/m2), tended to be older at hcc onset than patients within the normal weight range (bmi 18.5󈞅 kg/m2).

The results suggest that achieving an adequate body weight along with a reduction of alcohol intake in patients with chronic hepatitis C could help prevent hepatic carcinogenesis.

Explore further: NY and NJ say they will require Ebola quarantines

More information: Akiyama T, Mizuta T, Kawazoe S, Eguchi Y, Kawaguchi Y, Takahashi H, Ozaki I, Fujimoto K. Body mass index is associated with age-at-onset of HCV-infected hepatocellular carcinoma patients. World J Gastroenterol 2011; 17(7): 914-921. www.wjgnet.com/1007-9327/full/v17/i7/914.htm

add to favorites email to friend print save as pdf

Related Stories

If the diabetes has a direct carcinogenetic effect?

Oct 29, 2008

The association of DM2 with solid tumors, and particularly with HCC, has been long suspected and several studies have reported increased mortality rates for neoplastic diseases in patients with DM2. However, the temporal ...

Recommended for you

NY and NJ say they will require Ebola quarantines

1 hour ago

The governors of New Jersey and New York on Friday ordered a mandatory, 21-day quarantine for all doctors and other arriving travelers who have had contact with Ebola victims in West Africa.

WHO: Mali case may have infected many people

5 hours ago

The World Health Organization says a toddler who brought Ebola to Mali was bleeding from her nose during her journey on public transport and may have infected many people.

Two US nurses are declared cured of Ebola

6 hours ago

Two American nurses were declared cured of Ebola on Friday, and one was healthy enough to leave the hospital and meet President Barack Obama for a hug.

User comments : 0