Stroke incidence higher among patients with certain type of retinal vascular disease

Mar 14, 2011

Patients with a disease known as retinal vein occlusion (RVO) have a significantly higher incidence of stroke when compared with persons who do not have RVO, according to a report in the March issue of Archives of Ophthalmology, one of the JAMA/Archives journals.

" (RVO) is a retinal vascular disease in which a retinal vein is compressed by an adjacent retinal artery, resulting in turbulence, thrombus formation, and retinal ischemia," the authors write as background information in the article. "Although RVO is a significant cause of severe visual impairment in adults, it can occur at any age." Older age, diabetes, hypertension and vascular disease are among the for RVO.

Winifred Werther, Ph.D., then of Genentech Inc., South San Francisco, Calif., now of Vertex Pharmaceuticals, Cambridge, Mass., and colleagues conducted a retrospective cohort study to compare the incidence rates of (MI, ) and cerebrovascular accident (CVA, stroke) in hospitalized patients with and without retinal vein occlusion. The researchers used a U.S. population-based health care claims database to identify patients with RVO and control patients, matched for age and sex.

Among 4,500 patients with RVO and 13,500 control patients, the researchers found that patients with RVO had an almost two-fold higher incidence of stroke than the age- and sex-matched controls.

"Event rates for CVA were 1.16 and 0.52 per 100 person-years for RVO and controls, respectively," the authors report.

In contrast, event rates for heart attack were similar in the patients with RVO and the control patients.

"Although men and patients younger than 65 years with RVO had a 1.6- and 1.9-fold higher risk of MI, respectively, compared with controls, there were no statistically significant differences in MI rates between patients with RVO and controls when they were stratified by sex or age," the authors write.

They conclude that "these data suggest that physicians and patients should be aware of the possible increased risk of CVA but not of MI in patients with RVO."

Explore further: Ebola virus has mutated less than scientists feared, study finds

More information: Arch Ophthalmol, 2011;129[3]:326-331

add to favorites email to friend print save as pdf

Related Stories

Stroke victims experiencing seizures more likely to die

May 19, 2008

Seizures may be a sign of significant brain injury, and may occur in patients that experience any type of stroke. A new study finds that stroke patients with ensuing seizures are more likely to die in the 30 days following ...

Recommended for you

Nocturnal GERD tied to non-infectious rhinitis

2 hours ago

(HealthDay)—Nocturnal gastroesophageal reflux disease (GERD) appears to be a risk factor for non-infectious rhinitis (NIR), according to a study published online March 24 in Allergy.

UK nurse cured of Ebola after receiving new treatment

5 hours ago

A British army reservist who contracted Ebola while working as a volunteer nurse in Sierra Leone has fully recovered after becoming the first patient in the world to receive an experimental new treatment.

COPD takes big toll on employment, mobility in US

6 hours ago

(HealthDay)—The respiratory illness known as COPD takes a toll on mobility and employment, with a new report finding that nearly one-quarter of Americans with the condition are unable to work.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.