Clinical trial success for Crohn's disease cell therapy

Mar 31, 2011

Speaking at the UK National Stem Cell Network annual science meeting later today, Professor Miguel Forte will describe research into a new cell therapy for chronic inflammatory conditions such as Crohn's disease. Patient's own blood cells are used to produce a type of cell – Type 1 T regulatory lymphocyte – that can reduce the extent of the disease.

Professor Forte said "T regulatory lymphocytes are amazing cells – they secrete proteins – cytokines - that dampen down the over active immune response that causes the terrible symptoms of chronic inflammatory diseases such as Crohn's. We know that treatments based on these cells can work but the challenge is to develop them in the clinic so as to maximise the benefits and minimise the risk. We must show that these cells are well tolerated and do a good job to treat the disease."

Professor Forte and his colleagues at TxCell in Valbonne, France, have used patient's own immune system cells derived from PBMCs – a type of blood cell – to treat patients with chronic inflammatory diseases like Crohn's disease. They used these cells, from patients with Crohn's, who had previously been treated with drugs and/or surgery but still had significant symptoms due to treatment resistance to make Type 1 regulatory T lymphocytes, which were then given back to the patients. The purpose of the study was to assess how well patients react in general to the treatment and also to check the efficacy of these cells for treating Crohn's disease. The preliminary results presented today show a good tolerability and, when given the correct dose, patients with severe Crohn's disease that do not respond to other treatments have an improvement in their condition.

Cell therapy approaches, like this one and also MSCs, aim at using living cells as innovative new treatments to address unmet medical needs.

Professor Forte continued "It's still early days but the preliminary results are really good. The treatment didn't make the patients ill in any way and there is an early indication that their has improved. The next step will be to do what we call a "phase 2b" clinical trial to find out if the treatment definitely works, what types of chronic inflammatory disease it works for, more about any potential side effects and how to manage them, and to confirm our results on the best dose used."

Explore further: EU ready for Ebola threat: sources

add to favorites email to friend print save as pdf

Related Stories

ECP may be effective in treating Crohn's disease

May 25, 2007

(Washington, DC - May 23, 2007) -- Results from an international multi-center Phase II clinical trial suggest that extracorporeal photopheresis (ECP) may be effective in treating patients with clinically active (OR symptomatic) ...

Common parasite uncovers key cause of Crohn's

Feb 23, 2011

(PhysOrg.com) -- Immune systems have their sinister side, especially when they have not learned how hard to fight. Crohn's disease and other inflammatory bowel diseases inflict more than a million Americans ...

Recommended for you

EU ready for Ebola threat: sources

1 hour ago

The European Union is equipped and ready to treat victims should the deadly Ebola virus, which has killed hundreds in West Africa, be found in member states, EU sources said Wednesday.

Reducing kidney injury using a quality improvement method

6 hours ago

Using quality improvement measures in eight of the 10 hospitals in the Northern New England Cardiovascular Disease Study Group, researchers have found a way to reduce kidney injury in patients undergoing a procedure with ...

App for headache sufferers shows success

18 hours ago

A unique app that helps headache sufferers to record the severity and regularity of their pain is being used as part of a Griffith research study.

ACP expert discusses risks of biocontainment laboratories

19 hours ago

(HealthDay)—The risks emanating from biocontainment laboratories should be prevented by implementation of appropriate safety policies and procedures, according to an editorial published online July 29 in ...

User comments : 0