The embryogenesis evidence of foregut duplication cyst

Jan 25, 2011

A research team from United States reported two cases of gastric duplication cysts with a pseudostratified respiratory epithelium, with emphasis on their immunophenotype and embryogenesis. They explored the possible embryogenesis of these lesions in the light of thyroid transcription factor-1 and surfactant expression.

Foregut duplication cyst of the stomach is rare. Foregut duplications may or may not communicate with the , and are usually diagnosed at a young age. There have been relatively few case reports describing this entity. Adenocarcinoma has been reported in four cases of gastric duplication cyst, but not in cysts that have a ciliated epithelium. Controversy exists concerning the embryological origin of these anomalies.

A research article to be published on January 7, 2011 in the addresses this question. The authors presented two cases of gastric ciliated duplication cyst with emphasis on immunophenotype and embryogenesis.

Two cases showed that the cysts are lined with a pseudostratified respiratory epithelium with ciliated cells, which express thyroid transcription factor-1 and surfactant. This suggests an origin from the respiratory diverticulum, which arises from the ventral foregut and could also explain why these do or do not maintain their connection to the gastrointestinal tract.

Further research is required to explore the proposed mechanism. Better understanding of the embryogenesis of these could lead to early diagnosis or even prevention.

Explore further: Spicy treatment the answer to aggressive cancer?

More information: Khoury T, Rivera L. Foregut duplication cysts: A report of two cases with emphasis on embryogenesis. World J Gastroenterol 2011; 17(1): 130-134 www.wjgnet.com/1007-9327/full/v17/i1/130.htm

Related Stories

Multiple lipomas within jejunal duplication cyst

May 07, 2010

A research team from China reported a case of 68-year-old man complaining of abdominal bloating for 10 d due to multiple lipomas arising from jejunal duplication cysts. This case highlights intestinal lipoma as an uncommon ...

Gastric adenomyoma presenting as melena

Apr 20, 2010

A research team from China reported a case of 68-year-old man with gastric adenomyoma (AM) admitted to hospital for melana. They suggest that although gastric AM is rare, it should be considered in differential diagnosis ...

Laparoscopic approach to retrorectal cyst

Dec 01, 2008

Retrorectal cystic hamartoma (hindgut cyst) is a rare developmental lesion arising from the vestiges of the embryonic hind gut. Other developmental cysts can occur in retrorectal space. Anal gland cysts can develop near the ...

Researchers identify early ovarian cancers

Apr 26, 2010

Ovarian cancer kills nearly 15,000 women in the United States each year, and fewer than half of the women diagnosed with the disease survive five years. A screening test that detects ovarian cancer early, when it is still ...

Cysts hold clues to pancreatic cancer

Jun 03, 2010

Working with researchers from the University of Michigan and Indiana University, Van Andel Research Institute (VARI) investigators have developed a method that could be used to predict whether pancreatic cysts are benign ...

Recommended for you

Spicy treatment the answer to aggressive cancer?

Jul 03, 2015

It has been treasured by food lovers for thousands of years for its rich golden colour, peppery flavour and mustardy aroma…and now turmeric may also have a role in fighting cancer.

Cancer survivors who smoke perceive less risk from tobacco

Jul 02, 2015

Cancer survivors who smoke report fewer negative opinions about smoking, have more barriers to quitting, and are around other smokers more often than survivors who had quit before or after their diagnosis, according to a ...

Melanoma mutation rewires cell metabolism

Jul 02, 2015

A mutation found in most melanomas rewires cancer cells' metabolism, making them dependent on a ketogenesis enzyme, researchers at Winship Cancer Institute of Emory University have discovered.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.