Useful biomarkers for esophageal squamous cell carcinoma

January 25, 2011

A research team from China investigated the expression profile of miRNA in esophageal squamous cell carcinoma (ESCC). They found that miRNAs were deregulated and miR-143 and miR-145 were downregulated in ESCC.

MicroRNAs (miRNAs) regulate by mainly binding to the 3′-UTR of target mRNAs, leading to mRNA degradation or translation inhibition. Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies in China. Many studies have reported the expression profiles in Barrett's esophagus and esophageal adenocarcinoma. However, the pathobiological significance of aberrant miRNA expression in human ESCC has not been well documented.

A research article to be published on January 7, 2011 in the World Journal of Gastroenterology addresses this question. The authors reported the expression profile of miRNA in ESCC and investigated the expression and functions of miR-143 and miR-145 in ESCC.

The results showed that miRNAs were deregulated and miR-143 and miR-145 were downregulated in ESCC. Furthermore, rescued expression of miR-143 and miR-145 can inhibit cell mobility. This study provides the first evidence for the anti-oncogenic activity of miR-143 and miR-145 in the development of esophageal squamous cell cancer. Targets of these two miRNAs remain to be defined. These results indicate that miRNAs may eventually constitute useful biomarkers as well as therapeutic targets.

Explore further: Pair of microRNA molecules controls major oncogene in most common leukemia

More information: Wu BL, Xu LY, Du ZP, Liao LD, Zhang HF, Huang Q, Fang GQ, Li EM. MiRNA profile in esophageal squamous cell carcinoma: Downregulation of miR-143 and miR-145. World J Gastroenterol 2011; 17(1): 79-88. www.wjgnet.com/1007-9327/full/v17/i1/79.htm

Related Stories

MicroRNA controls expression of oncogenes

June 9, 2008

A new study demonstrates that microRNAs can modulate the expression of well known tumor-specific oncogenic translocation proteins and may play a significant role in some human cancers. The research, published by Cell Press ...

Scientists identify novel inhibitor of human microRNA

September 25, 2008

Scientists at The Wistar Institute and their colleagues have identified, for the first time, a molecule that can regulate microRNAs – short strands of RNA that play a vital role in gene expression and are closely associated ...

A biotherapy strategy for esophageal cancer in the future

April 19, 2010

A research team from China focused on esophageal squamous cell carcinoma (ESCC) and characterized sphingosine 1-phosphate (S1P) receptor expression pattern and investigated the role of S1P receptors on ESCC cells proliferation ...

Recommended for you

How the finch changes its tune

August 3, 2015

Like top musicians, songbirds train from a young age to weed out errors and trim variability from their songs, ultimately becoming consistent and reliable performers. But as with human musicians, even the best are not machines. ...

Machine Translates Thoughts into Speech in Real Time

December 21, 2009

(PhysOrg.com) -- By implanting an electrode into the brain of a person with locked-in syndrome, scientists have demonstrated how to wirelessly transmit neural signals to a speech synthesizer. The "thought-to-speech" process ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.