Useful biomarkers for esophageal squamous cell carcinoma

Jan 25, 2011

A research team from China investigated the expression profile of miRNA in esophageal squamous cell carcinoma (ESCC). They found that miRNAs were deregulated and miR-143 and miR-145 were downregulated in ESCC.

MicroRNAs (miRNAs) regulate by mainly binding to the 3′-UTR of target mRNAs, leading to mRNA degradation or translation inhibition. Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies in China. Many studies have reported the expression profiles in Barrett's esophagus and esophageal adenocarcinoma. However, the pathobiological significance of aberrant miRNA expression in human ESCC has not been well documented.

A research article to be published on January 7, 2011 in the World Journal of Gastroenterology addresses this question. The authors reported the expression profile of miRNA in ESCC and investigated the expression and functions of miR-143 and miR-145 in ESCC.

The results showed that miRNAs were deregulated and miR-143 and miR-145 were downregulated in ESCC. Furthermore, rescued expression of miR-143 and miR-145 can inhibit cell mobility. This study provides the first evidence for the anti-oncogenic activity of miR-143 and miR-145 in the development of esophageal squamous cell cancer. Targets of these two miRNAs remain to be defined. These results indicate that miRNAs may eventually constitute useful biomarkers as well as therapeutic targets.

Explore further: Docs face challenges treating HPV oropharyngeal CA patients

More information: Wu BL, Xu LY, Du ZP, Liao LD, Zhang HF, Huang Q, Fang GQ, Li EM. MiRNA profile in esophageal squamous cell carcinoma: Downregulation of miR-143 and miR-145. World J Gastroenterol 2011; 17(1): 79-88. www.wjgnet.com/1007-9327/full/v17/i1/79.htm

add to favorites email to friend print save as pdf

Related Stories

MicroRNA controls expression of oncogenes

Jun 09, 2008

A new study demonstrates that microRNAs can modulate the expression of well known tumor-specific oncogenic translocation proteins and may play a significant role in some human cancers. The research, published by Cell Press ...

A biotherapy strategy for esophageal cancer in the future

Apr 19, 2010

A research team from China focused on esophageal squamous cell carcinoma (ESCC) and characterized sphingosine 1-phosphate (S1P) receptor expression pattern and investigated the role of S1P receptors on ESCC cells proliferation ...

Scientists identify novel inhibitor of human microRNA

Sep 25, 2008

Scientists at The Wistar Institute and their colleagues have identified, for the first time, a molecule that can regulate microRNAs – short strands of RNA that play a vital role in gene expression and are closely associated ...

Recommended for you

Decoding the emergence of metastatic cancer stem cells

16 hours ago

In the first study of its kind, Rice University researchers have mapped how information flows through the genetic circuits that cause cancer cells to become metastatic. The research reveals a common pattern ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.