Method for manufacturing patient-specific human platelets

Nov 22, 2010

Skin cells from humans can be revamped into pro-clotting cells called platelets, according to a study published on November 22 in the Journal of Experimental Medicine. Patients with diseases causing thrombocytopenia—platelet deficiency—often require repeated transfusions with platelets obtained from healthy donors.

But donor platelet isolation is expensive and labor intensive, and donor platelets can be attacked by the patient's immune systems as "foreign." Therefore, Koji Eto and colleagues sought a method for generating custom-made platelets from patients' own cells.

The team first reprogrammed human skin cells to a more primitive, stem cell–like state; these cells were then cultured in a cocktail of platelet-promoting soluble factors. The resulting platelets circulated and accumulated in blood clots when injected into platelet-deficient mice, behaving just like normal platelets.

Although additional work is needed to ensure that the culture-derived platelets function like normal healthy platelets, these findings represent an important step toward making patient-specific clinically available.

Explore further: Scientists pioneer microscopy technique that yields fresh data on muscular dystrophy

More information: Takayama, N., et al. 2010. J. Exp. Med. doi:10.1084/jem.20100844

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Connection found between birth size and brain disorders

21 hours ago

(Medical Xpress)—A trio of researchers has found what appears to be a clear connection between birth size and weight, and the two brain disorders, autism and schizophrenia. In their paper published in Proceedings of ...

A novel therapy for sepsis?

Sep 16, 2014

A University of Tokyo research group has discovered that pentatraxin 3 (PTX3), a protein that helps the innate immune system target invaders such as bacteria and viruses, can reduce mortality of mice suffering ...

User comments : 0