In Brief: Bisphenol A causes sterility in roundworm

Nov 09, 2010

Bisphenol A can cause sterility and embryo death in a laboratory roundworm, according to a study published yesterday in the journal Proceedings of the National Academy of Sciences.

Long debated to cause an array of ailments, including , diabetes, and miscarriages, bisphenol A, found widely in plastics, lines most packaging for food and drink. A handful of states in the United States have banned the chemical in children's products, but nearly everyone is exposed to it.

Patrick Allard and Monica P. Colaiacovo tested the effects of bisphenol A on the cellular processes underlying the generation of sperm and eggs from their precursors in the roundworm Caenorhabditis elegans, an experimental model for molecular research.

The authors found that bisphenol A impairs certain DNA repair processes in sex cell precursors known to be essential for the formation of sperm and eggs. Further, exposure to bisphenol A damaged chromosomal integrity, triggered cells' damage surveillance systems, and led to .

Whereas controls appeared normal, the authors found frayed, fragmented, and aggregated chromosomes in egg cell precursors exposed to bisphenol A that ultimately led to embryo death and a drop in the worms' brood size.

The findings suggest a potential mechanism for the effect of on human reproduction, according to the authors.

Explore further: Education, breastfeeding and gender affect the microbes on our bodies

More information: "Bisphenol A impairs the double-strand break repair machinery in the germline and causes chromosome abnormalities," by Patrick Allard and Monica P. Colaiacovo, Proceedings of the National Academy of Sciences. www.pnas.org/

Provided by Proceedings of the National Academy of Sciences

not rated yet
add to favorites email to friend print save as pdf

Related Stories

Parent sue over bisphenol A in bottles

Nov 01, 2007

A group of California parents has filed a class-action lawsuit against manufacturers and sellers of baby bottles containing bisphenol A.

Canada set to label bisphenol A hazardous

Apr 15, 2008

Canada is set to be the first in the world to declare the widely used chemical bisphenol A a dangerous substance because of its estrogen-mimicking ability.

Plastics component affects intestine: study

Dec 14, 2009

The chemical Bisphenol A used in plastic containers and drinks cans has been shown for the first time to affect the functioning of the intestines, according to a French study published Monday.

Suspicion lingers over bisphenol A and breast cancer

Aug 25, 2006

Bisphenol A, a common industrial chemical claimed to speed the growth of human breast and ovarian cancers, retains its carcinogenic properties even after being modified by body processes, report Indiana University and University ...

Recommended for you

Leeches help save woman's ear after pit bull mauling

Apr 18, 2014

(HealthDay)—A pit bull attack in July 2013 left a 19-year-old woman with her left ear ripped from her head, leaving an open wound. After preserving the ear, the surgical team started with a reconnection ...

New pain relief targets discovered

Apr 17, 2014

Scientists have identified new pain relief targets that could be used to provide relief from chemotherapy-induced pain. BBSRC-funded researchers at King's College London made the discovery when researching ...

User comments : 0

More news stories

Treating depression in Parkinson's patients

A group of scientists from the University of Kentucky College of Medicine and the Sanders-Brown Center on Aging has found interesting new information in a study on depression and neuropsychological function in Parkinson's ...

Airbnb rental site raises $450 mn

Online lodging listings website Airbnb inked a $450 million funding deal with investors led by TPG, a source close to the matter said Friday.

Health care site flagged in Heartbleed review

People with accounts on the enrollment website for President Barack Obama's signature health care law are being told to change their passwords following an administration-wide review of the government's vulnerability to the ...