In Brief: Bisphenol A causes sterility in roundworm

November 9, 2010

Bisphenol A can cause sterility and embryo death in a laboratory roundworm, according to a study published yesterday in the journal Proceedings of the National Academy of Sciences.

Long debated to cause an array of ailments, including , diabetes, and miscarriages, bisphenol A, found widely in plastics, lines most packaging for food and drink. A handful of states in the United States have banned the chemical in children's products, but nearly everyone is exposed to it.

Patrick Allard and Monica P. Colaiacovo tested the effects of bisphenol A on the cellular processes underlying the generation of sperm and eggs from their precursors in the roundworm Caenorhabditis elegans, an experimental model for molecular research.

The authors found that bisphenol A impairs certain DNA repair processes in sex cell precursors known to be essential for the formation of sperm and eggs. Further, exposure to bisphenol A damaged chromosomal integrity, triggered cells' damage surveillance systems, and led to .

Whereas controls appeared normal, the authors found frayed, fragmented, and aggregated chromosomes in egg cell precursors exposed to bisphenol A that ultimately led to embryo death and a drop in the worms' brood size.

The findings suggest a potential mechanism for the effect of on human reproduction, according to the authors.

Explore further: Suspicion lingers over bisphenol A and breast cancer

More information: "Bisphenol A impairs the double-strand break repair machinery in the germline and causes chromosome abnormalities," by Patrick Allard and Monica P. Colaiacovo, Proceedings of the National Academy of Sciences. www.pnas.org/

Related Stories

Suspicion lingers over bisphenol A and breast cancer

August 25, 2006

Bisphenol A, a common industrial chemical claimed to speed the growth of human breast and ovarian cancers, retains its carcinogenic properties even after being modified by body processes, report Indiana University and University ...

Parent sue over bisphenol A in bottles

November 1, 2007

A group of California parents has filed a class-action lawsuit against manufacturers and sellers of baby bottles containing bisphenol A.

Canada set to label bisphenol A hazardous

April 15, 2008

Canada is set to be the first in the world to declare the widely used chemical bisphenol A a dangerous substance because of its estrogen-mimicking ability.

Plastics component affects intestine: study

December 14, 2009

The chemical Bisphenol A used in plastic containers and drinks cans has been shown for the first time to affect the functioning of the intestines, according to a French study published Monday.

Recommended for you

How the finch changes its tune

August 3, 2015

Like top musicians, songbirds train from a young age to weed out errors and trim variability from their songs, ultimately becoming consistent and reliable performers. But as with human musicians, even the best are not machines. ...

Machine Translates Thoughts into Speech in Real Time

December 21, 2009

(PhysOrg.com) -- By implanting an electrode into the brain of a person with locked-in syndrome, scientists have demonstrated how to wirelessly transmit neural signals to a speech synthesizer. The "thought-to-speech" process ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.