Female cancer patients find hope in fertility breakthrough

Oct 28, 2010 By Candace Gibson
Dr Kylie Dunning. Photo by Luke Simon.

University of Adelaide reproductive health researcher Dr. Kylie Dunning was last night named the 2010 Young Investigator Award winner for her work to help preserve the fertility of female cancer survivors.

Dr. Dunning, a postdoctoral researcher from the Robinson Institute and the Discipline of Obstetrics and Gynaecology at the University of Adelaide, examined the role of fat metabolism in the growth and development of in the laboratory.

"Major advances in medical research have led to improved cancer therapies and increased survival rates in patients, but the use of life-saving chemotherapy and often leads to infertility," Dr. Dunning says.

"In Australia, girls as young as 13 years old affected by cancer can have a portion of their ovaries cryopreserved for future use. What we've discovered may increase the chances of these women starting a family later in life.

"The latest technology for female fertility preservation involves growing ovarian tissue in a three-dimensional ball of gel in the lab, enabling eggs to grow and develop surrounded by their support cells, known collectively as the follicle."

This technology enables the growth of eggs in the laboratory that can then be fertilised and form embryos as in traditional IVF. In the future, these embryos could be returned to the womb to form a pregnancy and a healthy baby. By using this technology it avoids having to put back the cryopreserved ovarian tissue, which may contain .

Dr. Dunning says the use of 3-D follicle growth is extremely promising, however the growth of eggs capable of forming a healthy embryo and a baby requires further development.

"I've found that fats are a vital energy source for follicle and egg development. In fact, we've discovered that increasing the follicle and egg's utilisation of fat during 3-D follicle growth significantly improves subsequent ," Dr. Dunning says.

The Young Investigator Award, now in its 11th year, rewards scientific excellence in South Australia's young researchers and their ability to communicate and "sell" that science. The award final was held last night at The Sanctuary, at the Adelaide Zoo.

As winner, Dr. Dunning received The Hon Carolyn Pickles Award of $10,000. Prizes of $3000 each were awarded to the two runners up, Chantelle McIntyre and Zlatko Kopecki, who are both PhD candidates from the School of Paediatrics and Reproductive Health at the University of Adelaide.

Chantelle is investigating replacing defective genes to prevent brain deterioration in children with Sanfilippo Syndrome, a rare inherited disease where the body cannot metabolise sugar.

Zlatko is researching the role of a specific protein involved in genetic blister formation in fragile skin disorders, looking at reducing its levels to improve wound healing.

The award is an initiative of the Children, Youth and Women's Health Service and the Faculty of Health Sciences at the University of Adelaide.

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