c-Met may be a biomarker for metastatic hepatocellular carcinoma

Sep 28, 2010

Targeting c-Met may be a promising personalized treatment method for approximately 45 percent of patients with hepatocellular carcinoma (HCC) who have c-Met-positive tumors, according to study results presented at the Fourth AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development.

HCC is the most common primary of the liver; c-Met is a receptor for hepatocyte growth factor that appears to drive liver cancer growth, invasion and metastasis.

"Current therapies for HCC patients are 'one size fits all.' We propose that molecular profiling will enable better therapy for HCC patients with a c-Met positive tumor," said Hanning You, M.D., Ph.D., postdoctoral fellow working in the laboratory of C. Bart Rountree, M.D., in the departments of pediatrics and pharmacology, at the Pennsylvania State University College of Medicine, Hershey, Pa.

Using a preclinical translational study to validate c-Met as a target for HCC, You and colleagues found c-Met was highly overexpressed in metastatic liver cancer cells.

"By targeting c-Met we were able to suppress in vivo and kill these metastatic liver ," said You.

Since c-Met inhibitor stopped proliferation and tumor growth of metastatic HCC cells, the researchers concluded that c-Met might be a potential personalized target of metastatic HCC. In addition, they found that results of a separate meta-analysis of six studies and 1,051 patients showed that c-Met activation is associated with poor prognosis in HCC.

Explore further: A healthy lifestyle before bowel cancer diagnosis could help improve survival

Related Stories

New suppressor of common liver cancer

Dec 15, 2009

Tumor suppressor genes make proteins that help control cell growth. Mutations in these genes that generate nonfunctional proteins can contribute to tumor development and progression. One of the most well-known tumor suppressor ...

Genetic signatures provide new direction in liver cancer

Apr 16, 2010

Results of an international clinical study conducted in Europe and the US presented today at the International Liver Congress 2010, the Annual Meeting of the European Association for the Study of Liver in Vienna, Austria, ...

Hepatitis B virus mutations may predict risk of liver cancer

Jul 02, 2009

Certain mutations in the DNA of the hepatitis B virus (HBV) are associated with the development of liver cancer and may help predict which patients with HBV infections are at increased risk of the disease, according to a ...

Recommended for you

Psychologists aim to help Dr Google

6 hours ago

Psychologists are to improve online health information on lung cancer after research showed that family members are more likely to search online to encourage loved ones to seek help.

High-value research of 2014 presented for gastroenterology

8 hours ago

(HealthDay)—Articles relating to esophageal diseases, pancreatic cancer, colorectal cancer, inflammatory bowel disease, liver disease, and other topics are included in a special gastroenterology and hepatology ...

New method detects more breast cancer in screening

11 hours ago

Tomosynthesis detects 40% more breast cancers than traditional mammography does, according to a major screening study from Lund University, Sweden. This is the first large-scale study to compare the screening ...

Women's use of talc powder may be tied to ovarian cancer

May 05, 2015

Deane Berg's doctor called her in the day after Christmas 2006 to give her the crushing news. She'd had her ovaries removed, the pathology results were back, and the information could not have been much worse. Berg had stage ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.