Journal special edition outlines rotavirus burden and need for vaccines

November 5, 2009

The Journal of Infectious Diseases has released a special edition, Global Rotavirus Surveillance: Preparing for the Introduction of Rotavirus Vaccines. This special edition provides a significant contribution to the understanding of rotavirus disease burden and the impact of rotavirus vaccines, which have the potential to save an estimated 228,000 lives annually.

As the leading cause of severe diarrheal disease, rotavirus exacts a tremendous toll on health systems, particularly in the world's poorest countries. In addition to compiling data on rotavirus incidence from around the globe, this collection of scientific articles also covers strain diversity, the need for continued disease surveillance, and cost-effectiveness. The release of these pivotal data comes on the heels of the World Health Organization's (WHO) June 2009 recommendation that vaccines preventing rotavirus—the most common and lethal form of diarrheal disease—be included in every country's national immunization program.

Rotavirus is responsible for the death of more than half a million children under age 5 annually and causes approximately 40 percent of diarrhea-related hospitalizations. Nearly every child in the world, regardless of socio-economic status or geographic location, will contract rotavirus by age 3. However, its burden is disproportionally felt in developing countries in Africa and Asia, where rotavirus is often fatal because children cannot access emergency care.

"Rotavirus is one of the most deadly diseases children in the developing world face," said Dr. John Wecker, director of the Vaccine Access and Delivery Global Program at PATH. "Vaccination holds the key to making it one of the most preventable diseases."

Regional surveillance networks have generated rotavirus disease and strain burden data in nearly 60 countries since 2001, demonstrating tremendous burden and supporting the need for widespread rotavirus vaccine use. The WHO has advocated for the global introduction of rotavirus vaccines as a key component of the strategy to reduce child deaths from diarrheal disease—the second leading killer of children today.

"As these articles demonstrate, the burden of rotavirus is felt worldwide," said Marc-Alain Widdowson, epidemiologist at the U.S. Centers for Disease Control and Prevention and lead author of the introductory article in the special edition. "The global health community must work together with public and private sector partners to help every country use available interventions—including vaccines—to stop child diarrheal disease deaths."

Vaccines preventing rotavirus have been licensed in more than 100 countries, many of which are in the industrialized world, and their routine use is dramatically reducing severe infections. The vaccines have not yet reached many of the places where the rotavirus burden is greatest—especially in the developing countries of Africa and Asia.

"Vaccines are the best way to prevent rotavirus-related hospitalizations in industrialized countries and to avoid unnecessary child deaths in places where access to medical care and lifesaving interventions may be limited," said Dr. Duncan Steele, senior technical advisor for PATH's Vaccine Development Global Program and co-author of the introductory article in the special edition. Steele started his work on the article while at the WHO's Initiative for Vaccine Research.

Today, two orally administered vaccines preventing rotavirus, RotarixTM—produced by GlaxoSmithKline Biologicals, and RotaTeq®, produced by Merck—are available, and new vaccines are in development. The WHO recommendation on global use of these vaccines was based on large-scale clinical trials demonstrating vaccine efficacy in impoverished, high-mortality settings. It builds on a 2006 recommendation to include rotavirus vaccines in the national immunization programs of countries in Europe, Latin America, and North America. Informed by the WHO decision, the GAVI Alliance has committed to providing eligible countries with financial support for rotavirus vaccine introduction and is currently accepting applications.

More information: To access the Journal of supplement Global Rotavirus Surveillance: Preparing for the Introduction of Vaccines, please visit:

Source: Journal of Infectious Diseases

Explore further: Rotavirus can spread beyond the intestine

Related Stories

Rotavirus can spread beyond the intestine

April 17, 2007

A new study in PLoS Medicine has shown that children who have rotavirus, a very common cause of diarrhea in children, and who have antigens (protein fragments from the surface of the virus) in their blood, also have infectious ...

Falling birth rates shift rotavirus epidemics

July 16, 2009

Fewer births in states such as California may be delaying the annual onset of a common intestinal virus in the southwest, according to epidemiologists. The timing of infectious outbreaks in other locations such as the northeast ...

Study Suggests Affordable Vaccines Within Reach

November 3, 2009

( -- A new research paper suggests that pharmaceutical companies can afford to produce less expensive vaccines for lower-income countries because the companies can recover their research and development (R&D) ...

Recommended for you

How the finch changes its tune

August 3, 2015

Like top musicians, songbirds train from a young age to weed out errors and trim variability from their songs, ultimately becoming consistent and reliable performers. But as with human musicians, even the best are not machines. ...

Cow embryos reveal new type of chromosome chimera

May 27, 2016

I've often wondered what happens between the time an egg is fertilized and the time the ball of cells that it becomes nestles into the uterine lining. It's a period that we know very little about, a black box of developmental ...

Shaving time to test antidotes for nerve agents

February 29, 2016

Imagine you wanted to know how much energy it took to bike up a mountain, but couldn't finish the ride to the peak yourself. So, to get the total energy required, you and a team of friends strap energy meters to your bikes ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.