Tamiflu should not be given to children with flu: study (Update 2)

August 10, 2009

Children with seasonal flu should not be given Tamiflu because harmful side effects may outweigh relatively meagre benefits, according to a study released Monday.

In some Tamiflu caused nausea and vomiting, which can lead to dehydration and other complications, researchers reported.

The study did not cover the current outbreak of , but it suggests that may not significantly reduce the length of illness or prevent complications in children infected with the new A(H1N1) virus, the researchers said.

Carl Henegan, a doctor at John Radcliffe Hospital in Oxford and co-author of the study, said the current British practice of giving Tamiflu and Relenza -- the brand names for the antivirals oseltamivir and -- for mild illness was "an inappropriate strategy."

"The downside of the harms outweigh the one-day reduction in symptomatic benefits," he said.

The research showed that both antivirals shortened the duration of seasonal flu by 12 to 36 hours.

But the drugs had little or no effect on asthma flare-ups, increased ear infections or the need for antibiotics.

In addition, Tamiflu was linked to an increased risk of vomiting.

The study, published in the (BMJ), comes 10 days after Britain's Health Protection Agency (HPA) reported that more than half of 248 students given Tamiflu after a classmate fell ill with swine flu suffered side-effects such as nausea, insomnia and nightmares.

Most of the students did not have the flu when they were given the drug.

Vaccines are the frontline defence against influenza, but in Britain and elsewhere antivirals are often prescribed -- for treatment and prevention -- when vaccines are in low supply or simply unavailable, as in the case of swine flu.

The BMJ study, led by David Mant of Oxford University, concludes that a "more conservative strategy" in administering the drugs is probably in order.

The researchers reviewed four earlier clinical trials -- two with Relenza and two with Tamiflu -- for influenza treatment covering 1,766 children 12 or younger. More half had confirmed cases of type A flu.

They also reviewed three other trials in which the drugs were given to children who had been exposed to the virus but showed no symptoms.

Such "proactive" use resulted in only an eight percent reduction in the incidence of influenza, though earlier studies have shown a higher rate of protection.

None of the trials reviewed by the BMJ tested the efficacy of anti-virals against the new strain of swine flu that has swept across the globe since April, infecting hundreds of thousands and claiming more than 1,100 lives.

Swiss pharmaceutical company Roche, the patent holder of Tamiflu, suggested that the symptoms described in the study might been due in part to the flu itself and not the medication.

"According to the WHO, 50 percent of patients with the flu (swine or seasonal) have nausea symptoms or digestive problems caused by the illness," a Roche spokesman told AFP.

"Clinical studies on children treated with Tamiflu have shown secondary effects such as nausea, but these have been moderate and it is extremely rare that treatment must be halted as a consequence," the spokesman said.

Tamiflu is a so-called neuraminidase inhibitor that acts by blocking a viral enzyme that allows the virus to invade cells in the respiratory tract.

The drug can be prescribed from the age of one year old.

Severe symptoms in Japanese children taking reported earlier this decade -- delirium, hallucinations, encephalitis and 12 deaths -- were probably due to factors independent of the drug, according to several health authorities that investigated the cases, including the US Food and Drug Administration.

(c) 2009 AFP

Explore further: Flu drug advised for pregnant women with swine flu

Related Stories

Flu drug advised for pregnant women with swine flu

May 12, 2009

(AP) -- Pregnant women should take prescription flu medicines if they are diagnosed with the new swine flu, health officials said Tuesday. So far, the swine flu has not proven to be much more dangerous than seasonal influenza, ...

WHO urges restraint on Tamiflu in swine flu cases

May 13, 2009

(AP) -- With swine flu still spreading, the U.N. health agency is warning countries to limit their use of antiviral drugs to only high-risk patients to ensure adequate supplies in case the virus should mutate and become ...

Recommended for you

How the finch changes its tune

August 3, 2015

Like top musicians, songbirds train from a young age to weed out errors and trim variability from their songs, ultimately becoming consistent and reliable performers. But as with human musicians, even the best are not machines. ...

Machine Translates Thoughts into Speech in Real Time

December 21, 2009

(PhysOrg.com) -- By implanting an electrode into the brain of a person with locked-in syndrome, scientists have demonstrated how to wirelessly transmit neural signals to a speech synthesizer. The "thought-to-speech" process ...

1 comment

Adjust slider to filter visible comments by rank

Display comments: newest first

not rated yet Aug 11, 2009

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.